2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Jingmei Li; Linda S. Lindström; Jia N. Foo; Sajjad Rafiq; Marjanka K. Schmidt; Paul D.P. Pharoah; Kyriaki Michailidou; Joe Dennis; Manjeet K. Bolla; Qin Wang; Laura J. Van'T Veer; Sten Cornelissen; Emiel Rutgers; Melissa C. Southey; Carmel Apicella; Gillian S. Dite; John L. Hopper; Peter A. Fasching; Lothar Haeberle; Arif B. Ekici; Matthias W. Beckmann; Carl Blomqvist; Taru A. Muranen; Kristiina Aittomäki; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli Matti Kosma; Jaana M. Hartikainen; Vesa Kataja; Georgia Chenevix-Trench; Kconfab Investigators; Kelly Anne Phillips; Sue Anne McLachlan; Diether Lambrechts; Bernard Thienpont; Ann Smeets; Hans Wildiers; Jenny Chang-Claude; Dieter Flesch-Janys; Petra Seibold; Anja Rudolph; Graham G. Giles; Laura Baglietto; Gianluca Severi; Christopher A. Haiman; Brian E. Henderson; Fredrick Schumacher; Loic Le Marchand; Vessela Kristensen; Grethe I.Grenaker Alnæs; Anne Lise Borresen-Dale; Silje Nord; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Irene L. Andrulis; Julia A. Knight; Gord Glendon; Sandrine Tchatchou; Peter Devilee; Robert Tollenaar; Caroline Seynaeve; Maartje Hooning; Mieke Kriege; Antoinette Hollestelle; Ans Van Den Ouweland; Yi Li; Ute Hamann; Diana Torres; Hans U. Ulmer; Thomas Rüdiger; Chen Yang Shen; Chia Ni Hsiung; Pei Ei Wu; Shou Tung Chen; Soo Hwang Teo; Nur Aishah Mohd Taib; Cheng Har Yip; Gwo Fuang Ho; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Kazuo Tajima; Daehee Kang; Ji Yeob Choi; Sue K. Park; Keun Young Yoo; Tom Maishman; William J. Tapper; Alison Dunning; Mitul Shah; Robert Luben; Judith Brown; Chiea Chuen Khor; Diana M. Eccles; Heli Nevanlinna; Douglas Easton; Keith Humphreys; Jianjun Liu; Per Hall; Kamila Czene

doi:10.1038/ncomms5051

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

Jingmei Li, Linda S. Lindström, Jia N. Foo, Sajjad Rafiq, Marjanka K. Schmidt, Paul D.P. Pharoah, Kyriaki Michailidou, Joe Dennis, Manjeet K. Bolla, Qin Wang, Laura J. Van'T Veer, Sten Cornelissen, Emiel Rutgers, Melissa C. Southey, Carmel Apicella, Gillian S. Dite, John L. Hopper, Peter A. Fasching, Lothar Haeberle, Arif B. EkiciMatthias W. Beckmann, Carl Blomqvist, Taru A. Muranen, Kristiina Aittomäki, Annika Lindblom, Sara Margolin, Arto Mannermaa, Veli Matti Kosma, Jaana M. Hartikainen, Vesa Kataja, Georgia Chenevix-Trench, Kconfab Investigators, Kelly Anne Phillips, Sue Anne McLachlan, Diether Lambrechts, Bernard Thienpont, Ann Smeets, Hans Wildiers, Jenny Chang-Claude, Dieter Flesch-Janys, Petra Seibold, Anja Rudolph, Graham G. Giles, Laura Baglietto, Gianluca Severi, Christopher A. Haiman, Brian E. Henderson, Fredrick Schumacher, Loic Le Marchand, Vessela Kristensen, Grethe I.Grenaker Alnæs, Anne Lise Borresen-Dale, Silje Nord, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L. Andrulis, Julia A. Knight, Gord Glendon, Sandrine Tchatchou, Peter Devilee, Robert Tollenaar, Caroline Seynaeve, Maartje Hooning, Mieke Kriege, Antoinette Hollestelle, Ans Van Den Ouweland, Yi Li, Ute Hamann, Diana Torres, Hans U. Ulmer, Thomas Rüdiger, Chen Yang Shen, Chia Ni Hsiung, Pei Ei Wu, Shou Tung Chen, Soo Hwang Teo, Nur Aishah Mohd Taib, Cheng Har Yip, Gwo Fuang Ho, Keitaro Matsuo, Hidemi Ito, Hiroji Iwata, Kazuo Tajima, Daehee Kang, Ji Yeob Choi, Sue K. Park, Keun Young Yoo, Tom Maishman, William J. Tapper, Alison Dunning, Mitul Shah, Robert Luben, Judith Brown, Chiea Chuen Khor, Diana M. Eccles, Heli Nevanlinna, Douglas Easton, Keith Humphreys, Jianjun Liu, Per Hall, Kamila Czene

Research output: Contribution to journal › Article › peer-review

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Abstract

Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

Original language	English
Article number	4051
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms5051
Publication status	Published - 17 Jun 2014
Externally published	Yes

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10.1038/ncomms5051

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Li, J., Lindström, L. S., Foo, J. N., Rafiq, S., Schmidt, M. K., Pharoah, P. D. P., Michailidou, K., Dennis, J., Bolla, M. K., Wang, Q., Van'T Veer, L. J., Cornelissen, S., Rutgers, E., Southey, M. C., Apicella, C., Dite, G. S., Hopper, J. L., Fasching, P. A., Haeberle, L., ... Czene, K. (2014). 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nature Communications, 5, Article 4051. https://doi.org/10.1038/ncomms5051

@article{4e53493214ff42d7b67be86bfc8af2d9,

title = "2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy",

abstract = "Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 {\^a}{\^ }'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.",

author = "Jingmei Li and Lindstr{\"o}m, {Linda S.} and Foo, {Jia N.} and Sajjad Rafiq and Schmidt, {Marjanka K.} and Pharoah, {Paul D.P.} and Kyriaki Michailidou and Joe Dennis and Bolla, {Manjeet K.} and Qin Wang and {Van'T Veer}, {Laura J.} and Sten Cornelissen and Emiel Rutgers and Southey, {Melissa C.} and Carmel Apicella and Dite, {Gillian S.} and Hopper, {John L.} and Fasching, {Peter A.} and Lothar Haeberle and Ekici, {Arif B.} and Beckmann, {Matthias W.} and Carl Blomqvist and Muranen, {Taru A.} and Kristiina Aittom{\"a}ki and Annika Lindblom and Sara Margolin and Arto Mannermaa and Kosma, {Veli Matti} and Hartikainen, {Jaana M.} and Vesa Kataja and Georgia Chenevix-Trench and Kconfab Investigators and Phillips, {Kelly Anne} and McLachlan, {Sue Anne} and Diether Lambrechts and Bernard Thienpont and Ann Smeets and Hans Wildiers and Jenny Chang-Claude and Dieter Flesch-Janys and Petra Seibold and Anja Rudolph and Giles, {Graham G.} and Laura Baglietto and Gianluca Severi and Haiman, {Christopher A.} and Henderson, {Brian E.} and Fredrick Schumacher and {Le Marchand}, Loic and Vessela Kristensen and Aln{\ae}s, {Grethe I.Grenaker} and Borresen-Dale, {Anne Lise} and Silje Nord and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Andrulis, {Irene L.} and Knight, {Julia A.} and Gord Glendon and Sandrine Tchatchou and Peter Devilee and Robert Tollenaar and Caroline Seynaeve and Maartje Hooning and Mieke Kriege and Antoinette Hollestelle and {Van Den Ouweland}, Ans and Yi Li and Ute Hamann and Diana Torres and Ulmer, {Hans U.} and Thomas R{\"u}diger and Shen, {Chen Yang} and Hsiung, {Chia Ni} and Wu, {Pei Ei} and Chen, {Shou Tung} and Teo, {Soo Hwang} and Taib, {Nur Aishah Mohd} and {Har Yip}, Cheng and {Fuang Ho}, Gwo and Keitaro Matsuo and Hidemi Ito and Hiroji Iwata and Kazuo Tajima and Daehee Kang and Choi, {Ji Yeob} and Park, {Sue K.} and Yoo, {Keun Young} and Tom Maishman and Tapper, {William J.} and Alison Dunning and Mitul Shah and Robert Luben and Judith Brown and {Chuen Khor}, Chiea and Eccles, {Diana M.} and Heli Nevanlinna and Douglas Easton and Keith Humphreys and Jianjun Liu and Per Hall and Kamila Czene",

year = "2014",

month = jun,

day = "17",

doi = "10.1038/ncomms5051",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

}

Li, J, Lindström, LS, Foo, JN, Rafiq, S, Schmidt, MK, Pharoah, PDP, Michailidou, K, Dennis, J, Bolla, MK, Wang, Q, Van'T Veer, LJ, Cornelissen, S, Rutgers, E, Southey, MC, Apicella, C, Dite, GS, Hopper, JL, Fasching, PA, Haeberle, L, Ekici, AB, Beckmann, MW, Blomqvist, C, Muranen, TA, Aittomäki, K, Lindblom, A, Margolin, S, Mannermaa, A, Kosma, VM, Hartikainen, JM, Kataja, V, Chenevix-Trench, G, Investigators, K, Phillips, KA, McLachlan, SA, Lambrechts, D, Thienpont, B, Smeets, A, Wildiers, H, Chang-Claude, J, Flesch-Janys, D, Seibold, P, Rudolph, A, Giles, GG, Baglietto, L, Severi, G, Haiman, CA, Henderson, BE, Schumacher, F, Le Marchand, L, Kristensen, V, Alnæs, GIG, Borresen-Dale, AL, Nord, S, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Devilee, P, Tollenaar, R, Seynaeve, C, Hooning, M, Kriege, M, Hollestelle, A, Van Den Ouweland, A, Li, Y, Hamann, U, Torres, D, Ulmer, HU, Rüdiger, T, Shen, CY, Hsiung, CN, Wu, PE, Chen, ST, Teo, SH, Taib, NAM, Har Yip, C, Fuang Ho, G, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Kang, D, Choi, JY, Park, SK, Yoo, KY, Maishman, T, Tapper, WJ, Dunning, A, Shah, M, Luben, R, Brown, J, Chuen Khor, C, Eccles, DM, Nevanlinna, H, Easton, D, Humphreys, K, Liu, J, Hall, P & Czene, K 2014, '2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy', Nature Communications, vol. 5, 4051. https://doi.org/10.1038/ncomms5051

TY - JOUR

T1 - 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

AU - Li, Jingmei

AU - Lindström, Linda S.

AU - Foo, Jia N.

AU - Rafiq, Sajjad

AU - Schmidt, Marjanka K.

AU - Pharoah, Paul D.P.

AU - Michailidou, Kyriaki

AU - Dennis, Joe

AU - Bolla, Manjeet K.

AU - Wang, Qin

AU - Van'T Veer, Laura J.

AU - Cornelissen, Sten

AU - Rutgers, Emiel

AU - Southey, Melissa C.

AU - Apicella, Carmel

AU - Dite, Gillian S.

AU - Hopper, John L.

AU - Fasching, Peter A.

AU - Haeberle, Lothar

AU - Ekici, Arif B.

AU - Beckmann, Matthias W.

AU - Blomqvist, Carl

AU - Muranen, Taru A.

AU - Aittomäki, Kristiina

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Mannermaa, Arto

AU - Kosma, Veli Matti

AU - Hartikainen, Jaana M.

AU - Kataja, Vesa

AU - Chenevix-Trench, Georgia

AU - Investigators, Kconfab

AU - Phillips, Kelly Anne

AU - McLachlan, Sue Anne

AU - Lambrechts, Diether

AU - Thienpont, Bernard

AU - Smeets, Ann

AU - Wildiers, Hans

AU - Chang-Claude, Jenny

AU - Flesch-Janys, Dieter

AU - Seibold, Petra

AU - Rudolph, Anja

AU - Giles, Graham G.

AU - Baglietto, Laura

AU - Severi, Gianluca

AU - Haiman, Christopher A.

AU - Henderson, Brian E.

AU - Schumacher, Fredrick

AU - Le Marchand, Loic

AU - Kristensen, Vessela

AU - Alnæs, Grethe I.Grenaker

AU - Borresen-Dale, Anne Lise

AU - Nord, Silje

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Andrulis, Irene L.

AU - Knight, Julia A.

AU - Glendon, Gord

AU - Tchatchou, Sandrine

AU - Devilee, Peter

AU - Tollenaar, Robert

AU - Seynaeve, Caroline

AU - Hooning, Maartje

AU - Kriege, Mieke

AU - Hollestelle, Antoinette

AU - Van Den Ouweland, Ans

AU - Li, Yi

AU - Hamann, Ute

AU - Torres, Diana

AU - Ulmer, Hans U.

AU - Rüdiger, Thomas

AU - Shen, Chen Yang

AU - Hsiung, Chia Ni

AU - Wu, Pei Ei

AU - Chen, Shou Tung

AU - Teo, Soo Hwang

AU - Taib, Nur Aishah Mohd

AU - Har Yip, Cheng

AU - Fuang Ho, Gwo

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Iwata, Hiroji

AU - Tajima, Kazuo

AU - Kang, Daehee

AU - Choi, Ji Yeob

AU - Park, Sue K.

AU - Yoo, Keun Young

AU - Maishman, Tom

AU - Tapper, William J.

AU - Dunning, Alison

AU - Shah, Mitul

AU - Luben, Robert

AU - Brown, Judith

AU - Chuen Khor, Chiea

AU - Eccles, Diana M.

AU - Nevanlinna, Heli

AU - Easton, Douglas

AU - Humphreys, Keith

AU - Liu, Jianjun

AU - Hall, Per

AU - Czene, Kamila

PY - 2014/6/17

Y1 - 2014/6/17

N2 - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

AB - Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204-A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10 â ̂'9). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.

UR - http://www.scopus.com/inward/record.url?scp=84902763179&partnerID=8YFLogxK

U2 - 10.1038/ncomms5051

DO - 10.1038/ncomms5051

M3 - Article

C2 - 24937182

AN - SCOPUS:84902763179

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 4051

ER -

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy

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