A mouse plasma peptide atlas as a resource for disease proteomics

Qing Zhang, Rajasree Menon, Eric W. Deutsch, Sharon J. Pitteri, Vitor M. Faca, Hong Wang, Lisa F. Newcomb, Ronald A. DePinho, Nabeel Bardeesy, Daniela Dinulescu, Kenneth E. Hung, Raju Kucherlapati, Tyler Jacks, Katerina Politi, Ruedi Aebersold, Gilbert S. Omenn, David J. States, Samir M. Hanash

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20 Citations (Scopus)

Abstract

We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.

Original languageEnglish
Article numberR93
JournalGenome biology
Volume9
Issue number6
DOIs
Publication statusPublished - 3 Jun 2008
Externally publishedYes

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