A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis

M. Castedo; I. Vitale; G. Kroemer

doi:10.1038/onc.2010.392

A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis

M. Castedo, I. Vitale, G. Kroemer

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53. A recent article published in Cell by Davoli et al. shows that the simultaneous elimination of p53 and telomerase causes a state of chronic DNA damage that results in tetraploidization through endoreplication, that is, two consecutive S phases that are not separated by mitosis. As tetraploid cells represent a metastable intermediate between normal diploidy and cancer-associated aneuploidy, this novel route to tetraploidization may constitute (one of) the functional link(s) between aging and carcinogenesis.

Original language	English
Pages (from-to)	5869-5872
Number of pages	4
Journal	Oncogene
Volume	29
Issue number	44
DOIs	https://doi.org/10.1038/onc.2010.392
Publication status	Published - 4 Nov 2010

Keywords

aging
oncogenesis
telomere
tetraploidy

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10.1038/onc.2010.392

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title = "A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis",

abstract = "Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53. A recent article published in Cell by Davoli et al. shows that the simultaneous elimination of p53 and telomerase causes a state of chronic DNA damage that results in tetraploidization through endoreplication, that is, two consecutive S phases that are not separated by mitosis. As tetraploid cells represent a metastable intermediate between normal diploidy and cancer-associated aneuploidy, this novel route to tetraploidization may constitute (one of) the functional link(s) between aging and carcinogenesis.",

keywords = "aging, oncogenesis, telomere, tetraploidy",

author = "M. Castedo and I. Vitale and G. Kroemer",

note = "Funding Information: GK was supported by the Ligue Nationale contre le Cancer (Equipes labellis{\'e}e), Agence Nationale pour la Recherche (ANR), European Commission (Active p53, Apo-Sys, Chemo Res, ApopTrain), Fondation pour la Recherche M{\'e}dicale (FRM), Institut National du Cancer (INCa) and Canc{\'e}rop{\^o}le Ile-de-France. IV was supported by the Ligue Nationale contre le Cancer.",

year = "2010",

month = nov,

day = "4",

doi = "10.1038/onc.2010.392",

language = "English",

volume = "29",

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T1 - A novel source of tetraploid cancer cell precursors

T2 - Telomere insufficiency links aging to oncogenesis

AU - Castedo, M.

AU - Vitale, I.

AU - Kroemer, G.

N1 - Funding Information: GK was supported by the Ligue Nationale contre le Cancer (Equipes labellisée), Agence Nationale pour la Recherche (ANR), European Commission (Active p53, Apo-Sys, Chemo Res, ApopTrain), Fondation pour la Recherche Médicale (FRM), Institut National du Cancer (INCa) and Cancéropôle Ile-de-France. IV was supported by the Ligue Nationale contre le Cancer.

PY - 2010/11/4

Y1 - 2010/11/4

N2 - Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53. A recent article published in Cell by Davoli et al. shows that the simultaneous elimination of p53 and telomerase causes a state of chronic DNA damage that results in tetraploidization through endoreplication, that is, two consecutive S phases that are not separated by mitosis. As tetraploid cells represent a metastable intermediate between normal diploidy and cancer-associated aneuploidy, this novel route to tetraploidization may constitute (one of) the functional link(s) between aging and carcinogenesis.

AB - Epithelial cancers of the elderly are caused by a combination of telomere dysfunction and the mutational invalidation of major tumor suppressors including p53. A recent article published in Cell by Davoli et al. shows that the simultaneous elimination of p53 and telomerase causes a state of chronic DNA damage that results in tetraploidization through endoreplication, that is, two consecutive S phases that are not separated by mitosis. As tetraploid cells represent a metastable intermediate between normal diploidy and cancer-associated aneuploidy, this novel route to tetraploidization may constitute (one of) the functional link(s) between aging and carcinogenesis.

KW - aging

KW - oncogenesis

KW - telomere

KW - tetraploidy

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U2 - 10.1038/onc.2010.392

DO - 10.1038/onc.2010.392

M3 - Review article

C2 - 20802535

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SN - 0950-9232

VL - 29

SP - 5869

EP - 5872

JO - Oncogene

JF - Oncogene

IS - 44

ER -

A novel source of tetraploid cancer cell precursors: Telomere insufficiency links aging to oncogenesis

Abstract

Keywords

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