A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine

Cécile Nozières, Thomas Walter, Marie Odile Joly, Sophie Giraud, Jean Yves Scoazec, Françoise Borson-Chazot, Chantal Simon, Jean Paul Riou, Catherine Lombard-Bohas

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19 Citations (Scopus)

Abstract

Ten percent of paragangliomas are malignant and one-third occurs in a genetic background. We report a case of succinate dehydrogenase subunit B (SDHB)-related malignant paraganglioma with dramatic response to temozolomide and capecitabine regimen (decrease in tumor size of 70% with RECIST criteria). Tumor cells harbored a new mutation in SDHB gene and showed aberrant hypermethylation of O6-methylguanine-DNA-methyltransferase promoter. Our report suggests the importance of molecular predictive factors of response for the selection of chemotherapeutic as well as targeted agents. This observation points to a possible genotype response to treatment relationships, which could help to design tailor-made treatments in the future.

Original languageEnglish
Pages (from-to)1107-1111
Number of pages5
JournalEuropean Journal of Endocrinology
Volume166
Issue number6
DOIs
Publication statusPublished - 1 Jun 2012
Externally publishedYes

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