AID and partners: For better and (not) for worse

Sébastien Storck; Said Aoufouchi; Jean Claude Weill; Claude Agnès Reynaud

doi:10.1016/j.coi.2011.02.002

AID and partners: For better and (not) for worse

Sébastien Storck, Said Aoufouchi, Jean Claude Weill, Claude Agnès Reynaud

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

Abstract

Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.

Original language	English
Pages (from-to)	337-344
Number of pages	8
Journal	Current Opinion in Immunology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.coi.2011.02.002
Publication status	Published - 1 Jun 2011
Externally published	Yes

Access to Document

10.1016/j.coi.2011.02.002

Cite this

@article{c66d3227e18f49438579f22305427b98,

title = "AID and partners: For better and (not) for worse",

abstract = "Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.",

author = "S{\'e}bastien Storck and Said Aoufouchi and Weill, {Jean Claude} and Reynaud, {Claude Agn{\`e}s}",

year = "2011",

month = jun,

day = "1",

doi = "10.1016/j.coi.2011.02.002",

language = "English",

volume = "23",

pages = "337--344",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

number = "3",

}

TY - JOUR

T1 - AID and partners

T2 - For better and (not) for worse

AU - Storck, Sébastien

AU - Aoufouchi, Said

AU - Weill, Jean Claude

AU - Reynaud, Claude Agnès

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.

AB - Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.

UR - http://www.scopus.com/inward/record.url?scp=79955639340&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2011.02.002

DO - 10.1016/j.coi.2011.02.002

M3 - Review article

C2 - 21439803

AN - SCOPUS:79955639340

SN - 0952-7915

VL - 23

SP - 337

EP - 344

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 3

ER -

AID and partners: For better and (not) for worse

Abstract

Access to Document

Other files and links

Cite this