TY - JOUR
T1 - Alterations of the putative tumor suppressor gene p16/MTS1 in human hematological malignancies
AU - Duro, D.
AU - Flexor, M. A.
AU - Bernard, O.
AU - D'Agay, M. F.
AU - Berger, R.
AU - Larsen, C. J.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The chromosome band 9p21-22 is frequently rearranged or deleted in a variety of tumors including hematological malignancies. This supports the notion of a tumor suppressor gene in this chromosome region. Indeed, the p16/MTS1 gene encoding a cyclin-dependant kinase (CDK) inhibitor has been shown to be frequently deleted and/or inactivated by nonsense mutations in a number of tumors. We have examined 98 DNA samples from blood, bone marrow cells and lymph node biopsies of patients with leukemia (ALL and AML) or lymphoma (follicular lymphoma and T-cell lymphoma), using Southern blot hybridization and a p16/MTS1-specific probe. Molecular abnormalities, mainly homozygous deletions, were found principally in ALL (8 out of 22 patients), much less frequently in AML (2/32) and lymphoma (2/32). While these data argue in favor of a large involvement of p16/MTS1 in ALL, AML and lymphomas appear to be less frequently implicated.
AB - The chromosome band 9p21-22 is frequently rearranged or deleted in a variety of tumors including hematological malignancies. This supports the notion of a tumor suppressor gene in this chromosome region. Indeed, the p16/MTS1 gene encoding a cyclin-dependant kinase (CDK) inhibitor has been shown to be frequently deleted and/or inactivated by nonsense mutations in a number of tumors. We have examined 98 DNA samples from blood, bone marrow cells and lymph node biopsies of patients with leukemia (ALL and AML) or lymphoma (follicular lymphoma and T-cell lymphoma), using Southern blot hybridization and a p16/MTS1-specific probe. Molecular abnormalities, mainly homozygous deletions, were found principally in ALL (8 out of 22 patients), much less frequently in AML (2/32) and lymphoma (2/32). While these data argue in favor of a large involvement of p16/MTS1 in ALL, AML and lymphomas appear to be less frequently implicated.
KW - deletion
KW - hematological malignancies
KW - leukemias
KW - mutation
KW - tumor suppressor genes
UR - http://www.scopus.com/inward/record.url?scp=0028104513&partnerID=8YFLogxK
M3 - Article
C2 - 7882134
AN - SCOPUS:0028104513
SN - 0764-4469
VL - 317
SP - 913
EP - 919
JO - Comptes Rendus de l'Academie des Sciences - Serie III
JF - Comptes Rendus de l'Academie des Sciences - Serie III
IS - 10
ER -