An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla; Ilio Vitale; Isabelle Martins; Oliver Kepp; Lorenzo Galluzzi; Laurence Zitvoge; Maria Castedo; Guido Kroemer

doi:10.4161/onco.22409

An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Laura Senovilla, Ilio Vitale, Isabelle Martins, Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvoge, Maria Castedo, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

One of the driving forces of oncogenesis is tetraploidy, a duplication of the DNA content that, upon asymmetric cell division or progressive chromosome loss, can originate aneuploidy. Recent findings from our group indicate the existence of an immunosurveillance system that eliminates tetraploid cancer cells. We surmise that tetraploidy-inducing chemotherapeutic agents may elicit potent anticancer responses by re-activating this immunosurveillance system.

Original language	English
Article number	e22409
Journal	OncoImmunology
Volume	2
Issue number	1
DOIs	https://doi.org/10.4161/onco.22409
Publication status	Published - 1 Jan 2013

Keywords

Breast carcinoma
Calreticulin
HMGB1
Hyperploidy
Immunogenic cell death
Mitotic catastrophe

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10.4161/onco.22409

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AU - Martins, Isabelle

AU - Kepp, Oliver

AU - Galluzzi, Lorenzo

AU - Zitvoge, Laurence

AU - Castedo, Maria

AU - Kroemer, Guido

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KW - Breast carcinoma

KW - Calreticulin

KW - HMGB1

KW - Hyperploidy

KW - Immunogenic cell death

KW - Mitotic catastrophe

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An anticancer therapy-elicited immunosurveillance system that eliminates tetraploid cells

Abstract

Keywords

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