TY - JOUR
T1 - Antitumour activity of somatostatin analogues in sporadic, progressive, metastatic pulmonary carcinoids
AU - Sullivan, Ivana
AU - Le Teuff, Gwénaël
AU - Guigay, Joël
AU - Caramella, Caroline
AU - Berdelou, Amandine
AU - Leboulleux, Sophie
AU - Déandréis, Désirée
AU - Hadoux, Julien
AU - Ducreux, Michel
AU - Duvillard, Pierre
AU - Adam, Julien
AU - Scoazec, Jean Yves
AU - Baudin, Eric
AU - Planchard, David
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Purpose Antiproliferative activity of somatostatin analogues (SSAs) has been demonstrated in digestive neuroendocrine tumours but few data have been published on pulmonary carcinoids (PC). The aim of this retrospective study was to report the antitumour activity of SSAs in patients with progressive, metastatic PC. Methods Patients with PC and treated with SSA monotherapy were reviewed. Disease was classified according to the tumour slope prior to SSA initiation as rapidly progressive (at least 20% increase in the sum of the longest diameter of target lesions or the appearance of one or more new lesions within 6 months) or slowly progressive (if progression occurred over 6 months). Survival outcomes were progression-free survival (PFS) and overall survival (OS). We additionally examined the overall response rate and safety. Prognostic factors associated with PFS and OS were sought. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox model. Results Among 67 patients reviewed, 61 were included in the study. Forty-one (67%) of them exhibited slowly progressive disease prior to SSAs, 41 (67%) had atypical carcinoids and 29 (48%) had functioning tumours. Forty-six (76%) patients had received SSAs as first-line therapy. The best overall response was stable disease in 47 (77%) patients. The median duration of SSAs was 13.7 months. With a median follow-up of 5.8 years, median PFS and OS were 17.4 (95% CI: 8.7–26.0) and 58.4 (95% CI: 44.2–102.7) months, respectively. Functioning tumours and slowly progressive disease were significantly associated with longer PFS: HR = 0.48 ([95% CI: 0.24–0.95], p = 0.03) and HR = 7.43 ([95% CI: 3.02–18.25], p < 0.0001), respectively. Only functioning tumours remained significantly associated with OS: HR = 0.33 ([95% CI: 0.14–0.79], p = 0.01). Treatment had been discontinued in two patients due to side-effects. Conclusions Median PFS observed in our study is encouraging for PC patients. Patients with functioning tumours and slowly progressive disease treated with SSAs have better prognosis.
AB - Purpose Antiproliferative activity of somatostatin analogues (SSAs) has been demonstrated in digestive neuroendocrine tumours but few data have been published on pulmonary carcinoids (PC). The aim of this retrospective study was to report the antitumour activity of SSAs in patients with progressive, metastatic PC. Methods Patients with PC and treated with SSA monotherapy were reviewed. Disease was classified according to the tumour slope prior to SSA initiation as rapidly progressive (at least 20% increase in the sum of the longest diameter of target lesions or the appearance of one or more new lesions within 6 months) or slowly progressive (if progression occurred over 6 months). Survival outcomes were progression-free survival (PFS) and overall survival (OS). We additionally examined the overall response rate and safety. Prognostic factors associated with PFS and OS were sought. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox model. Results Among 67 patients reviewed, 61 were included in the study. Forty-one (67%) of them exhibited slowly progressive disease prior to SSAs, 41 (67%) had atypical carcinoids and 29 (48%) had functioning tumours. Forty-six (76%) patients had received SSAs as first-line therapy. The best overall response was stable disease in 47 (77%) patients. The median duration of SSAs was 13.7 months. With a median follow-up of 5.8 years, median PFS and OS were 17.4 (95% CI: 8.7–26.0) and 58.4 (95% CI: 44.2–102.7) months, respectively. Functioning tumours and slowly progressive disease were significantly associated with longer PFS: HR = 0.48 ([95% CI: 0.24–0.95], p = 0.03) and HR = 7.43 ([95% CI: 3.02–18.25], p < 0.0001), respectively. Only functioning tumours remained significantly associated with OS: HR = 0.33 ([95% CI: 0.14–0.79], p = 0.01). Treatment had been discontinued in two patients due to side-effects. Conclusions Median PFS observed in our study is encouraging for PC patients. Patients with functioning tumours and slowly progressive disease treated with SSAs have better prognosis.
KW - Antitumour activity
KW - Metastatic disease
KW - Pulmonary carcinoids
KW - Somatostatin analogues
UR - http://www.scopus.com/inward/record.url?scp=85013824059&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2016.11.034
DO - 10.1016/j.ejca.2016.11.034
M3 - Article
C2 - 28242503
AN - SCOPUS:85013824059
SN - 0959-8049
VL - 75
SP - 259
EP - 267
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -