TY - JOUR
T1 - Applying ecological and evolutionary theory to cancer
T2 - A long and winding road
AU - Thomas, Frédéric
AU - Fisher, Daniel
AU - Fort, Philippe
AU - Marie, Jean Pierre
AU - Daoust, Simon
AU - Roche, Benjamin
AU - Grunau, Christoph
AU - Cosseau, Céline
AU - Mitta, Guillaume
AU - Baghdiguian, Stephen
AU - Rousset, François
AU - Lassus, Patrice
AU - Assenat, Eric
AU - Grégoire, Damien
AU - Missé, Dorothée
AU - Lorz, Alexander
AU - Billy, Frédérique
AU - Vainchenker, William
AU - Delhommeau, François
AU - Koscielny, Serge
AU - Itzykson, Raphael
AU - Tang, Ruoping
AU - Fava, Fanny
AU - Ballesta, Annabelle
AU - Lepoutre, Thomas
AU - Krasinska, Liliana
AU - Dulic, Vjekoslav
AU - Raynaud, Peggy
AU - Blache, Philippe
AU - Quittau-Prevostel, Corinne
AU - Vignal, Emmanuel
AU - Trauchessec, Hélène
AU - Perthame, Benoit
AU - Clairambault, Jean
AU - Volpert, Vitali
AU - Solary, Eric
AU - Hibner, Urszula
AU - Hochberg, Michael E.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
AB - Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies). Historically, little attention has been placed on applications of evolutionary biology to understanding and controlling neoplastic progression and to prevent therapeutic failures. This is now beginning to change, and there is a growing international interest in the interface between cancer and evolutionary biology. The objective of this introduction is first to describe the basic ideas and concepts linking evolutionary biology to cancer. We then present four major fronts where the evolutionary perspective is most developed, namely laboratory and clinical models, mathematical models, databases, and techniques and assays. Finally, we discuss several of the most promising challenges and future prospects in this interdisciplinary research direction in the war against cancer.
KW - Cancer, disease biology
KW - Evolutionary medicine
KW - Evolutionary theory
UR - http://www.scopus.com/inward/record.url?scp=84872759734&partnerID=8YFLogxK
U2 - 10.1111/eva.12021
DO - 10.1111/eva.12021
M3 - Article
AN - SCOPUS:84872759734
SN - 1752-4563
VL - 6
SP - 1
EP - 10
JO - Evolutionary Applications
JF - Evolutionary Applications
IS - 1
ER -