TY - JOUR
T1 - Approches cliniques et thérapeutiques des maladies trophoblastiques
AU - Lhommé, Catherine
AU - Pautier, Patricia
AU - Morice, Philippe
AU - Bidart, Jean Michel
AU - Duvillard, Pierre
PY - 1998/12/1
Y1 - 1998/12/1
N2 - The diagnosis of gestational trophoblastic tumors (GTT) (hydatiform mole, invasive mole, choriocarcinoma, placental-site trophoblastic tumor) is suggested by gynecological symptoms, elevated hCG long after a pregnancy or through detection of a metastasis. The diagnosis is based on histological sample and/or an elevated hCG level. As the specificity and sensitivity of plasma hCG determinations -are very high, hCG and β-hCG determinations are of paramount importance for the initial diagnosis, and during follow-up (during and after treatment). Chemotherapy has totally transformed the prognosis of GTT but within this group coexist tumors with differing prognosis. Several studies have identified diverse prognostic factors. Various classifications are described, but none is universal. Once the diagnosis is made, patients undergo clinical, biological and radiological examinations to determine the prognosis. So, treatment can be tailored to fit each case (chemotherapy or not, protocol of chemotherapy, surgery or not). Efficient contraception must be prescribed throughout the duration of treatment and during follow up. Another pregnancy can be allowed 6 months after a good prognosis GTT and 1 year after a poor prognosis GTT.
AB - The diagnosis of gestational trophoblastic tumors (GTT) (hydatiform mole, invasive mole, choriocarcinoma, placental-site trophoblastic tumor) is suggested by gynecological symptoms, elevated hCG long after a pregnancy or through detection of a metastasis. The diagnosis is based on histological sample and/or an elevated hCG level. As the specificity and sensitivity of plasma hCG determinations -are very high, hCG and β-hCG determinations are of paramount importance for the initial diagnosis, and during follow-up (during and after treatment). Chemotherapy has totally transformed the prognosis of GTT but within this group coexist tumors with differing prognosis. Several studies have identified diverse prognostic factors. Various classifications are described, but none is universal. Once the diagnosis is made, patients undergo clinical, biological and radiological examinations to determine the prognosis. So, treatment can be tailored to fit each case (chemotherapy or not, protocol of chemotherapy, surgery or not). Efficient contraception must be prescribed throughout the duration of treatment and during follow up. Another pregnancy can be allowed 6 months after a good prognosis GTT and 1 year after a poor prognosis GTT.
KW - Chemotherapy
KW - Management
KW - Prognosis factors
KW - Trophoblastic disease
UR - http://www.scopus.com/inward/record.url?scp=2242464033&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:2242464033
SN - 0994-3919
VL - 11
SP - 453
EP - 456
JO - Reproduction Humaine et Hormones
JF - Reproduction Humaine et Hormones
IS - 5
ER -