TY - JOUR
T1 - Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer
T2 - Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses
AU - Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE)
AU - the Colorectal Transdisciplinary Study (CORECT)
AU - Transdisciplinary Research in Cancer of the Lung (TRICL)
AU - Transdisciplinary Research in Cancer of the Lung (TRICL)
AU - Khankari, Nikhil K.
AU - Shu, Xiao Ou
AU - Wen, Wanqing
AU - Kraft, Peter
AU - Lindström, Sara
AU - Peters, Ulrike
AU - Schildkraut, Joellen
AU - Schumacher, Fredrick R.
AU - Bofetta, Paolo
AU - Risch, Angela
AU - Bickeböller, Heike
AU - Amos, Christopher I.
AU - Easton, Douglas F.
AU - Eeles, Rosalind A.
AU - Gruber, Stephen B.
AU - Haiman, Christopher A.
AU - Hunter, David J.
AU - Chanock, Stephen J.
AU - Pierce, Brandon L.
AU - Zheng, Wei
AU - Blalock, Kendra
AU - Campbell, Peter T.
AU - Casey, Graham
AU - Conti, David V.
AU - Edlund, Christopher K.
AU - Figueiredo, Jane
AU - James Gauderman, W.
AU - Gong, Jian
AU - Green, Roger C.
AU - Harju, John F.
AU - Harrison, Tabitha A.
AU - Jacobs, Eric J.
AU - Jenkins, Mark A.
AU - Jiao, Shuo
AU - Li, Li
AU - Lin, Yi
AU - Manion, Frank J.
AU - Moreno, Victor
AU - Mukherjee, Bhramar
AU - Raskin, Leon
AU - Seminara, Daniela
AU - Severi, Gianluca
AU - Stenzel, Stephanie L.
AU - Thomas, Duncan C.
AU - Hopper, John L.
AU - Southey, Melissa C.
AU - Makalic, Enes
AU - Schmidt, Daniel F.
AU - Fletcher, Olivia
AU - Peto, Julian
N1 - Publisher Copyright:
© 2016 This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings: A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Using meta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height with cancer risk. Mendelian randomization analyses were conducted using summary statistics obtained for 423 genetic variants identified from a recent GWAS of adult height and from a cancer genetics consortium study of multiple cancers that included 47,800 cases and 81,353 controls. For a 10-cm increase in height, the summary relative risks derived from the meta-analyses of prospective studies were 1.12 (95% CI 1.10, 1.15), 1.07 (95% CI 1.05, 1.10), and 1.06 (95% CI 1.02, 1.11) for colorectal, prostate, and lung cancers, respectively. Mendelian randomization analyses showed increased risks of colorectal (odds ratio [OR] = 1.58, 95% CI 1.14, 2.18) and lung cancer (OR = 1.10, 95% CI 1.00, 1.22) associated with each 10-cm increase in genetically predicted height. No association was observed for prostate cancer (OR = 1.03, 95% CI 0.92, 1.15). Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate. Conclusions: Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.
AB - Background: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings: A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Using meta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height with cancer risk. Mendelian randomization analyses were conducted using summary statistics obtained for 423 genetic variants identified from a recent GWAS of adult height and from a cancer genetics consortium study of multiple cancers that included 47,800 cases and 81,353 controls. For a 10-cm increase in height, the summary relative risks derived from the meta-analyses of prospective studies were 1.12 (95% CI 1.10, 1.15), 1.07 (95% CI 1.05, 1.10), and 1.06 (95% CI 1.02, 1.11) for colorectal, prostate, and lung cancers, respectively. Mendelian randomization analyses showed increased risks of colorectal (odds ratio [OR] = 1.58, 95% CI 1.14, 2.18) and lung cancer (OR = 1.10, 95% CI 1.00, 1.22) associated with each 10-cm increase in genetically predicted height. No association was observed for prostate cancer (OR = 1.03, 95% CI 0.92, 1.15). Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate. Conclusions: Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.
UR - http://www.scopus.com/inward/record.url?scp=84989836123&partnerID=8YFLogxK
U2 - 10.1371/journal.pmed.1002118
DO - 10.1371/journal.pmed.1002118
M3 - Article
C2 - 27598322
AN - SCOPUS:84989836123
SN - 1549-1277
VL - 13
JO - PLoS Medicine
JF - PLoS Medicine
IS - 9
M1 - e1002118
ER -