TY - JOUR
T1 - Association between alcohol consumption and DNA methylation in blood
T2 - A systematic review of observational studies
AU - Dragic, Dzevka
AU - Chang, Sue Ling
AU - Ennour-Idrissi, Kaoutar
AU - Durocher, Francine
AU - Severi, Gianluca
AU - Diorio, Caroline
N1 - Publisher Copyright:
© 2022 Future Medicine Ltd.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Aim: We systematically reviewed and evaluated current literature on alcohol consumption and DNA methylation (DNAm) at the genome-wide and probe-wise level in blood of adults. Materials & methods: Five databases (PubMed, Embase, Web of Science, CINAHL and PsycInfo) were searched until 20 December 2020. Studies assessing the effect of alcohol dependence on DNAm were not eligible. Results: 11 cross-sectional studies were included with 88 to 9643 participants. Overall, all studies had a risk of bias criteria unclear or unmet. Epigenome-wide association studies identified between 0 and 5458 differentially methylated positions, and 15 were observed in at least four studies. Conclusion: Potential methylation markers for alcohol consumption have been identified, but further validation in large cohorts is needed.
AB - Aim: We systematically reviewed and evaluated current literature on alcohol consumption and DNA methylation (DNAm) at the genome-wide and probe-wise level in blood of adults. Materials & methods: Five databases (PubMed, Embase, Web of Science, CINAHL and PsycInfo) were searched until 20 December 2020. Studies assessing the effect of alcohol dependence on DNAm were not eligible. Results: 11 cross-sectional studies were included with 88 to 9643 participants. Overall, all studies had a risk of bias criteria unclear or unmet. Epigenome-wide association studies identified between 0 and 5458 differentially methylated positions, and 15 were observed in at least four studies. Conclusion: Potential methylation markers for alcohol consumption have been identified, but further validation in large cohorts is needed.
KW - DMP
KW - DNA methylation
KW - alcohol consumption
KW - blood
KW - differentially methylated positions
KW - epigenetic biomarkers
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85134214379&partnerID=8YFLogxK
U2 - 10.2217/epi-2022-0055
DO - 10.2217/epi-2022-0055
M3 - Review article
C2 - 35762294
AN - SCOPUS:85134214379
SN - 1750-1911
VL - 14
SP - 793
EP - 810
JO - Epigenomics
JF - Epigenomics
IS - 12
ER -