Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors

Guido Kroemer, Lorenzo Galluzzi

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.

    Original languageEnglish
    Pages (from-to)5686-5691
    Number of pages6
    JournalOncotarget
    Volume8
    Issue number4
    DOIs
    Publication statusPublished - 1 Jan 2017

    Keywords

    • ATP
    • Chloroquine
    • Damage-associated molecular patterns
    • Doxorubicin
    • Immunogenic cell death
    • Radiation therapy

    Cite this