Autophagy in the cancer-immunity dialogue

Takahiro Yamazaki, José Manuel Bravo-San Pedro, Lorenzo Galluzzi, Guido Kroemer, Federico Pietrocola

    Research output: Contribution to journalReview articlepeer-review

    57 Citations (Scopus)

    Abstract

    Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic cells, explaining why both normal and malignant cells benefit from proficient autophagic responses. Moreover, autophagy is intimately involved in the immunological control of malignant transformation, tumor progression and response to therapy. However, the net effect of autophagy activation or inhibition on the natural growth or therapeutic response of tumors evolving in immunocompetent hosts exhibits a considerable degree of context dependency. Here, we discuss the complex cross-talk between autophagy and immuno-oncology as delineated by genetic and pharmacological approaches in mouse models of cancer.

    Original languageEnglish
    Pages (from-to)40-50
    Number of pages11
    JournalAdvanced Drug Delivery Reviews
    Volume169
    DOIs
    Publication statusPublished - 1 Feb 2021

    Keywords

    • ATG5
    • Antigen presentation
    • Beclin 1
    • CGAS/STING signaling
    • Cytotoxic T lymphocytes
    • Dendritic cells
    • Mitophagy
    • T cells

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