TY - JOUR
T1 - Autophagy in the Pathogenesis of Disease
AU - Levine, Beth
AU - Kroemer, Guido
N1 - Funding Information:
B.L. is supported by the National Institutes of Health, American Cancer Society, and Ellison Medical Foundation. G.K. is supported by Ligue Nationale contre le Cancer, Agence Nationale de Recherche, Institut National contre le Cancer, Cancéropôle Ile-de France, and European Union (Active p53, ApoSys, ChemoRes, DeathTrain, RIGHT, TransDeath). We thank R. Talley for administrative assistance and M. Packer for helpful comments.
PY - 2008/1/11
Y1 - 2008/1/11
N2 - Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
AB - Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.
UR - http://www.scopus.com/inward/record.url?scp=37649005234&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2007.12.018
DO - 10.1016/j.cell.2007.12.018
M3 - Review article
C2 - 18191218
AN - SCOPUS:37649005234
SN - 0092-8674
VL - 132
SP - 27
EP - 42
JO - Cell
JF - Cell
IS - 1
ER -