Abstract
Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.
Original language | English |
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Pages (from-to) | 2125-2127 |
Number of pages | 3 |
Journal | Oncogene |
Volume | 28 |
Issue number | 21 |
DOIs |
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Publication status | Published - 28 May 2009 |
Keywords
- Autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria