Beclin 1: A BH3-only protein that fails to induce apoptosis

P. Boya, G. Kroemer

    Research output: Contribution to journalComment/debate

    31 Citations (Scopus)

    Abstract

    Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.

    Original languageEnglish
    Pages (from-to)2125-2127
    Number of pages3
    JournalOncogene
    Volume28
    Issue number21
    DOIs
    Publication statusPublished - 28 May 2009

    Keywords

    • Autophagy; apoptosis; Bcl-2, Beclin-1; endoplasmic reticulum; mitochondria

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