Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinoma

Jonathan G. Pol, Juliette Paillet, Céleste Plantureux, Guido Kroemer

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    Abstract

    It has been an open conundrum why primary sclerosing cholangitis (PSC) is a major risk factor for developing cholangiocarcinoma (CAA), while primary biliary cholangitis (PBC) is not. In mouse models of PSC and PBC, it turned out that the latter condition, an autoimmune disease affecting the bile ducts, reduces transgene-induced cholangiocarcinogenesis, as well as the progression of subcutaneously implanted CCA. This CCA-delaying effect is lost upon depletion of T lymphocytes and involves tumor infiltration by T cell clonotypes that are also found in PBC lesions. Hence, organ-specific autoimmunity may improve immunosurveillance.

    Original languageEnglish
    Article number1968595
    JournalOncoImmunology
    Volume10
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2021

    Keywords

    • Cancer immunosurveillance
    • T lymphocytes
    • autoimmunity
    • cholangiocarcinoma
    • primary biliary cholangitis

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