Bone marrow necrosis and human parvovirus associated infection preceding an phl + acute lymphoblastic leukemia

Tony Petrella, Francois Bailly, Francine Mugneret, Denis Caillot, Pascal Chavanet, Henri Guy, Eric Solary, Anne Waldner, Elisabeth Devilliers, Paule Marie Carli, Robert Michiels

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Abstract

A case of bone marrow necrosis associated with a serologically documented recent Parvovirus B 19 infection which preceded the development of PH1+ acute lymphoblastic leukemia is reported. No conclusions can be drawn on the basis of a single case but the question of the role of human Parvovirus B19 in the pathogenesis of bone marrow necrosis is discussed. It is suggested that the virus may act as a co-factor for the induction of bone marrow necrosis, in some cases.

Original languageEnglish
Pages (from-to)415-419
Number of pages5
JournalLeukemia and Lymphoma
Volume8
Issue number4-5
DOIs
Publication statusPublished - 1 Jan 1992
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Bone marrow necrosis
  • Parvovirus infection
  • Philadelphia chromosome

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