Boosting Immunity by Targeting Post-translational Prenylation of Small GTPases

Caroline Robert, Stéphan Vagner

Research output: Contribution to journalShort surveypeer-review

6 Citations (Scopus)

Abstract

Diseases leading to immune activation and autoinflammatory phenotypes may provide a reservoir of potentially druggable pathways for optimizing immune adjuvants or boosting antitumor immune responses. Now, Xia et al. report that lipophilic statins or biphosphonates, targeting the mevalonate pathway, act as efficient vaccine adjuvants and synergize with anti-PD1 against cancer. Diseases leading to immune activation and autoinflammatory phenotypes may provide a reservoir of potentially druggable pathways for optimizing immune adjuvants or boosting antitumor immune responses. Now, Xia et al. report that lipophilic statins or biphosphonates, targeting the mevalonate pathway, act as efficient vaccine adjuvants and synergize with anti-PD1 against cancer.

Original languageEnglish
Pages (from-to)901-902
Number of pages2
JournalCell
Volume175
Issue number4
DOIs
Publication statusPublished - 1 Nov 2018
Externally publishedYes

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