TY - JOUR
T1 - Breast cancer following radiotherapy for a hemangioma during childhood
AU - Haddy, Nadia
AU - Dondon, Marie Gabrielle
AU - Paoletti, Catherine
AU - Rubino, Carole
AU - Mousannif, Abdeddahir
AU - Shamsaldin, Akhtar
AU - Doyon, Françoise
AU - Labbé, Martine
AU - Robert, Caroline
AU - Avril, Marie Françoise
AU - Demars, Rogers
AU - Molinie, Florence
AU - Lefkopoulos, Dimitri
AU - Diallo, Ibrahima
AU - De Vathaire, Florent
N1 - Funding Information:
Acknowledgments This work was supported by the Fondation de France, the Ligue Nationale Contre le Cancer (LNCC), and European Commission contract F14P-CT95-0009. The authors are grateful to Lorna Saint Ange for editing. We thank Pr Franc¸ois Eschwege, Pr Jean Chavaudra, and Dr Philippe Fragu for their help in accomplishing this study.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Purpose: A cohort study was performed to investigate the carcinogenic effect of treatment of skin hemangioma with ionizing radiation in early childhood. This paper presents the incidence of breast cancer (BC) in this cohort and its association with radiotherapy. Methods and materials: In an incidence study, 3,316 women treated for a skin hemangioma between 1941 and 1977 at the Institut Gustave-Roussy were included, among whom 2,697 had received radiotherapy. The mean age at first exposure was 0.7 years, and the mean absorbed dose to the breast was 70 mGy. Treatment reconstruction and the estimation of radiation doses delivered to the breast were obtained for 92% of the women who had received radiotherapy. External and internal analyses were performed. Results: During an average follow-up of 35 years, a total of 17 women developed an invasive BC, compared to 7.5 expected in the French general population (SIR = 2.3, 95% CI, 1.4-3.5), and the absolute excess risk strongly increased with attained age. Compared to individuals with no radiotherapy, the risk of BC increased with increasing radiation dose with RRs of 3.2, 6.3, and 8.0 for dose categories of >0-10, 10-100, and >100 mGy, respectively; however, dose-response relationship was not significant. Conclusion: This study confirms that radiation treatment performed in the past for hemangioma during childhood increases the risk of BC.
AB - Purpose: A cohort study was performed to investigate the carcinogenic effect of treatment of skin hemangioma with ionizing radiation in early childhood. This paper presents the incidence of breast cancer (BC) in this cohort and its association with radiotherapy. Methods and materials: In an incidence study, 3,316 women treated for a skin hemangioma between 1941 and 1977 at the Institut Gustave-Roussy were included, among whom 2,697 had received radiotherapy. The mean age at first exposure was 0.7 years, and the mean absorbed dose to the breast was 70 mGy. Treatment reconstruction and the estimation of radiation doses delivered to the breast were obtained for 92% of the women who had received radiotherapy. External and internal analyses were performed. Results: During an average follow-up of 35 years, a total of 17 women developed an invasive BC, compared to 7.5 expected in the French general population (SIR = 2.3, 95% CI, 1.4-3.5), and the absolute excess risk strongly increased with attained age. Compared to individuals with no radiotherapy, the risk of BC increased with increasing radiation dose with RRs of 3.2, 6.3, and 8.0 for dose categories of >0-10, 10-100, and >100 mGy, respectively; however, dose-response relationship was not significant. Conclusion: This study confirms that radiation treatment performed in the past for hemangioma during childhood increases the risk of BC.
KW - Breast cancer
KW - Childhood
KW - Cohort
KW - Hemangioma
KW - Radiation
UR - http://www.scopus.com/inward/record.url?scp=78449308777&partnerID=8YFLogxK
U2 - 10.1007/s10552-010-9607-5
DO - 10.1007/s10552-010-9607-5
M3 - Article
C2 - 20607383
AN - SCOPUS:78449308777
SN - 0957-5243
VL - 21
SP - 1807
EP - 1816
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 11
ER -