TY - JOUR
T1 - Cancer-Induced Endoplasmic Reticulum Stress in T Cells Subverts Immunosurveillance
AU - López-Soto, Alejandro
AU - Kroemer, Guido
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/12/4
Y1 - 2018/12/4
N2 - Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses. Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.
AB - Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses. Compelling evidence indicates that tumors may evade immunosurveillance by subverting the metabolism of immune cells. In a recent paper in Nature, Song et al. (2018) demonstrate that ovarian cancers activate IRE1α-XBP1 signaling within CD4+ T lymphocytes, thereby disrupting their bioenergetic function and contribution to anticancer immune responses.
UR - http://www.scopus.com/inward/record.url?scp=85056990859&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2018.11.003
DO - 10.1016/j.cmet.2018.11.003
M3 - Short survey
C2 - 30517892
AN - SCOPUS:85056990859
SN - 1550-4131
VL - 28
SP - 803
EP - 805
JO - Cell Metabolism
JF - Cell Metabolism
IS - 6
ER -