Cancer médullaire de la thyroïde (CMT) de l'enfant

Amandine Berdelou; Dana Hartl; Abir Al Ghuzlan; Haïtham Mirghani; Cécile Chougnet; Éric Baudin; Martin Schlumberger; Sophie Leboulleux

doi:10.1684/bdc.2013.1775

Cancer médullaire de la thyroïde (CMT) de l'enfant

Translated title of the contribution: Medullary thyroid carcinoma in children

Amandine Berdelou, Dana Hartl, Abir Al Ghuzlan, Haïtham Mirghani, Cécile Chougnet, Éric Baudin, Martin Schlumberger, Sophie Leboulleux

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Medullary thyroid carcinoma (MTC) is rare in children. MTC is almost always inherited and occurs as part of a multiple endocrine neoplasia type 2A and B, due to germline mutation in the RET proto-oncogene. MTC in the pediatric population is most often diagnosed in the course of a familial genetic investigation. But when the child is the proband, a de novo mutation is most often founded. The main aim is to treat MTC before extrathyroidal extension occurs because when distant metastases are present, it is rarely curable. Treatment is based on total thyroidectomy with cervical lymph node dissection.

Translated title of the contribution	Medullary thyroid carcinoma in children
Original language	French
Pages (from-to)	780-788
Number of pages	9
Journal	Bulletin du Cancer
Volume	100
Issue number	7-8
DOIs	https://doi.org/10.1684/bdc.2013.1775
Publication status	Published - 1 Jan 2013

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title = "Cancer m{\'e}dullaire de la thyro{\"i}de (CMT) de l'enfant",

abstract = "Medullary thyroid carcinoma (MTC) is rare in children. MTC is almost always inherited and occurs as part of a multiple endocrine neoplasia type 2A and B, due to germline mutation in the RET proto-oncogene. MTC in the pediatric population is most often diagnosed in the course of a familial genetic investigation. But when the child is the proband, a de novo mutation is most often founded. The main aim is to treat MTC before extrathyroidal extension occurs because when distant metastases are present, it is rarely curable. Treatment is based on total thyroidectomy with cervical lymph node dissection.",

keywords = "Hereditary disease, Medullary thyroid carcinoma, Multiple endocrine neoplasia",

author = "Amandine Berdelou and Dana Hartl and {Al Ghuzlan}, Abir and Ha{\"i}tham Mirghani and C{\'e}cile Chougnet and {\'E}ric Baudin and Martin Schlumberger and Sophie Leboulleux",

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T1 - Cancer médullaire de la thyroïde (CMT) de l'enfant

AU - Berdelou, Amandine

AU - Hartl, Dana

AU - Al Ghuzlan, Abir

AU - Mirghani, Haïtham

AU - Chougnet, Cécile

AU - Baudin, Éric

AU - Schlumberger, Martin

AU - Leboulleux, Sophie

PY - 2013/1/1

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N2 - Medullary thyroid carcinoma (MTC) is rare in children. MTC is almost always inherited and occurs as part of a multiple endocrine neoplasia type 2A and B, due to germline mutation in the RET proto-oncogene. MTC in the pediatric population is most often diagnosed in the course of a familial genetic investigation. But when the child is the proband, a de novo mutation is most often founded. The main aim is to treat MTC before extrathyroidal extension occurs because when distant metastases are present, it is rarely curable. Treatment is based on total thyroidectomy with cervical lymph node dissection.

AB - Medullary thyroid carcinoma (MTC) is rare in children. MTC is almost always inherited and occurs as part of a multiple endocrine neoplasia type 2A and B, due to germline mutation in the RET proto-oncogene. MTC in the pediatric population is most often diagnosed in the course of a familial genetic investigation. But when the child is the proband, a de novo mutation is most often founded. The main aim is to treat MTC before extrathyroidal extension occurs because when distant metastases are present, it is rarely curable. Treatment is based on total thyroidectomy with cervical lymph node dissection.

KW - Hereditary disease

KW - Medullary thyroid carcinoma

KW - Multiple endocrine neoplasia

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M3 - Article

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SN - 0007-4551

VL - 100

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EP - 788

JO - Bulletin du Cancer

JF - Bulletin du Cancer

IS - 7-8

ER -

Cancer médullaire de la thyroïde (CMT) de l'enfant

Abstract

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