CANTO-RT: Skin toxicities evaluation of a multicentre large prospective cohort of irradiated patients for early-stage breast cancer

Sofiane Allali, Matthieu Carton, Thomas Sarrade, Ophélie Querel, Alexandra Jacquet, Sofia Rivera, Youssef Ghannam, Karine Peignaux, Philippe Guilbert, Claire Chara-Brunaud, Julien Blanchecotte, David Pasquier, Séverine Racadot, Céline Bourgier, Alain Labib, Julien Geffrelot, Ahmed Benyoucef, François Paris, Paul Cottu, Fabrice AndréYoulia Kirova

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    6 Citations (Scopus)

    Abstract

    Skin damage is the most common and most important toxicity during and after radiation therapy (RT). Its assessment and understanding of the factors influencing its occurrence, is a major issue in the management of patients irradiated for an early breast cancer. CANTO is a prospective clinical cohort study of 10 150 patients with stage I-III BC treated from 2012 to 2017 in 26 cancer centres. In our study, we used CANTO-RT, a subcohort of CANTO, including 3480 patients who received RT. We are focus on specific skin toxicities: erythema, fibrosis, telangiectasia and cutaneous pigmentation. The prevalence of toxicities of interest varied over time, so at baseline for early toxicity Month (M) 0-3-6, 41.1% of patients had erythema while 24.8% of patients had fibrosis. At M12 and M36, the prevalence of erythema decreased, respectively, while fibrosis remains stable. The prevalence of telangiectasia increases from 1% to 7.1% from M0-3-6 to M36. After adjustments, we showed an association between the occurrence of skin erythema and obesity; the type of surgery; the presence of axillary dissection; the use of taxane-based CT and the 3D vs IMRT irradiation technique. Regarding fibrosis, an association is found, at M0-3-6, with age at diagnosis, obesity, tobacco and the use of boost. Only obesity and the type of surgery received by the patient remained statistically significant at M12 and M36. In our study we identified several risk factors for acute and late skin reactions. The use of a boost was mainly related to the occurrence of fibrosis while the use of IMRT-type technique decreased the occurrence of skin erythema.

    Original languageEnglish
    Pages (from-to)1098-1108
    Number of pages11
    JournalInternational Journal of Cancer
    Volume151
    Issue number7
    DOIs
    Publication statusPublished - 1 Oct 2022

    Keywords

    • breast cancer
    • erythema
    • fibrosis
    • radiotherapy
    • skin toxicity

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