TY - JOUR
T1 - Case Report
T2 - Response to Immunotherapy, Can Radiotherapy Be a Troublemaker?
AU - Martin-Romano, Patricia
AU - Adam, Julien
AU - Scoazec, Jean Yves
AU - Gouy, Sébastien
AU - Levy, Antonin
AU - Baldini, Capucine
AU - Champiat, Stéphane
AU - Soria, Jean Charles
AU - Massard, Christophe
AU - Marabelle, Aurélien
AU - Deutsch, Eric
AU - Hollebecque, Antoine
N1 - Publisher Copyright:
© Copyright © 2021 Martin-Romano, Adam, Scoazec, Gouy, Levy, Baldini, Champiat, Soria, Massard, Marabelle, Deutsch and Hollebecque.
PY - 2021/11/4
Y1 - 2021/11/4
N2 - Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.
AB - Immunotherapy has dramatically changed the treatment landscape for several tumor types. However, the impact of previous radiotherapy (RT) on response to immunotherapy is still unknown. We report the case of a 58-year-old female diagnosed with a squamous anal cell carcinoma previously treated with RT and having a dissociated response to anti-PD1 agent. An extensive analysis of the immune contexture performed on the tissue collected from both previously RT-treated and RT-untreated lesions confirmed differences on immune microenvironment, highlighting the potential impact of radiotherapy on the immune response.
KW - anal squamous cell carcinoma
KW - immune microenvironment
KW - immunotherapy
KW - radiation therapy
KW - tumor response
UR - http://www.scopus.com/inward/record.url?scp=85119401758&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.745146
DO - 10.3389/fimmu.2021.745146
M3 - Article
C2 - 34804027
AN - SCOPUS:85119401758
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 745146
ER -