Cellular interactions in nasopharyngeal carcinomas

Claire Gourzones, Jihène Klibi-Benlagha, Luc Friboulet, Rachid Jlidi, Pierre Busson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Citations (Scopus)

Abstract

Tumor cell population in nasopharyngeal carcinomas (NPC) is highly heterogeneous. In addition of being heavily infiltrated by nonmalignant leucocytes, malignant NPC cells can display various phenotypes in terms of epithelial maturation and viral gene expression. These various cell sub-populations communicate through membrane contacts, secretion of cytokines and exosomes. Understanding their interactions is crucial for the elucidation of tumor growth and immune escape as well as for designing better therapeutic approaches. This chapter deals with three major questions. (1) What are the local factors responsible for leucocyte attraction and retention in NPC tumors? (2) What are the suspected autocrine and paracrine mechanisms of tumor growth? (3) What are the mechanisms of tumor immune evasion which could explain the growth of malignant epithelial cells containing viral antigenic proteins in a context of local inflammation?.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages82-100
Number of pages19
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume778
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • CNE2 cell
  • Cellular interaction
  • Malignant epithelial cell
  • Nasopharyngeal carcinoma
  • Stromal fibroblast

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