TY - JOUR
T1 - Checkpoint Blockade Plus Oncolytic Virus
T2 - A Hot Therapeutic Cancer Strategy
AU - Robert, Caroline
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/11/1
Y1 - 2017/11/1
N2 - How can we transform an immune desert into a ‘hot tumor’ that is prone to respond to anti-programmed death (PD)-1 immunotherapy? This might be possible by injecting an oncolytic virus, engineered to induce local immune stimulation, prior to anti-PD-1 therapy. A recent study demonstrated that this combination – evaluated in a Phase Ib metastatic melanoma clinical study – yields promising results.
AB - How can we transform an immune desert into a ‘hot tumor’ that is prone to respond to anti-programmed death (PD)-1 immunotherapy? This might be possible by injecting an oncolytic virus, engineered to induce local immune stimulation, prior to anti-PD-1 therapy. A recent study demonstrated that this combination – evaluated in a Phase Ib metastatic melanoma clinical study – yields promising results.
UR - http://www.scopus.com/inward/record.url?scp=85033691383&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2017.09.008
DO - 10.1016/j.molmed.2017.09.008
M3 - Short survey
C2 - 29137714
AN - SCOPUS:85033691383
SN - 1471-4914
VL - 23
SP - 983
EP - 985
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 11
ER -