Checkpoint immunologique comme cible thérapeutique

Translated title of the contribution: Immune checkpoints as a target treatment

S. Champiat, A. Marabelle

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    New immunotherapies targeting immune checkpoints can induce prolonged antitumor responses and increased survival. Rather than trying to induce a specific immune response with vaccine strategies, these new agents seek to overcome tumor immunosuppression by inhibiting the immune response inhibitors and thus release the brakes on the immune system. The anti-CTLA-4 ipilimumab was the first of these treatments to be approved in 2011 for advanced melanoma. Since then, other inhibitory pathways are targeted and early results obtained with anti-PD-1 and anti-PD-L1 show very promising results with durable responses and lower toxicity. Their specific profile of responses and toxicities are currently challenging our oncology practice. Also, combination studies with conventional therapies will help us to better define the future strategies of treatment.

    Translated title of the contributionImmune checkpoints as a target treatment
    Original languageFrench
    Pages (from-to)354-371
    Number of pages18
    JournalOncologie
    Volume17
    Issue number9
    DOIs
    Publication statusPublished - 26 Sept 2015

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