Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch; Florence Nguyen-Khac; Olivier A. Bernard

doi:10.1111/bjh.14719

Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch, Florence Nguyen-Khac, Olivier A. Bernard

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients’ perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.

Original language	English
Pages (from-to)	852-870
Number of pages	19
Journal	British Journal of Haematology
Volume	178
Issue number	6
DOIs	https://doi.org/10.1111/bjh.14719
Publication status	Published - 1 Sept 2017

Keywords

chronic lymphocytic leukaemia
mutations
targeted therapy
tumour evolution

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10.1111/bjh.14719

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Chronic lymphocytic leukaemia genomics and the precision medicine era

Abstract

Keywords

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