TY - JOUR
T1 - Circulating tumor cells (CTCs) for the noninvasive monitoring and personalization of non-small cell lung cancer (NSCLC) therapies
AU - Pawlikowska, Patrycja
AU - Faugeroux, Vincent
AU - Oulhen, Marianne
AU - Aberlenc, Agathe
AU - Tayoun, Tala
AU - Pailler, Emma
AU - Farace, Françoise
N1 - Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Growing evidences for tumor heterogeneity confirm that single-tumor biopsies frequently fail to reveal the widespread mutagenic profile of tumor. Repeated biopsies are in most cases unfeasible, especially in advanced cancers. We describe here how circulating tumor cells (CTCs) isolated from minimally invasive blood sample might inform us about intratumor heterogeneity, tumor evolution and treatment resistance. We also discuss the advances of CTCs research, most notably in molecularly selected non-small cell lung cancer (NSCLC) patients, highlighting challenges and opportunities related to personalized therapy.
AB - Growing evidences for tumor heterogeneity confirm that single-tumor biopsies frequently fail to reveal the widespread mutagenic profile of tumor. Repeated biopsies are in most cases unfeasible, especially in advanced cancers. We describe here how circulating tumor cells (CTCs) isolated from minimally invasive blood sample might inform us about intratumor heterogeneity, tumor evolution and treatment resistance. We also discuss the advances of CTCs research, most notably in molecularly selected non-small cell lung cancer (NSCLC) patients, highlighting challenges and opportunities related to personalized therapy.
KW - Circulating tumor cells (CTC)
KW - Liquid biopsy
KW - Non-small cell lung cancer (NSCLC)
UR - http://www.scopus.com/inward/record.url?scp=85061152347&partnerID=8YFLogxK
U2 - 10.21037/jtd.2018.12.80
DO - 10.21037/jtd.2018.12.80
M3 - Review article
AN - SCOPUS:85061152347
SN - 2072-1439
VL - 11
SP - S45-S56
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
ER -