Clinical use of ferric carboxymaltose in patients with solid tumours or haematological malignancies in France

Alain Toledano, Elisabeth Luporsi, Jean François Morere, Florian Scotté, Kamel Laribi, Jérôme Barrière, Philippe Huot-Marchand, Ladan Duvillié, Victor Hugo Concas, Roland Bugat

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30 Citations (Scopus)

Abstract

Purpose: This study collected data on the use of ferric carboxymaltose (FCM) in a cancer patient population in France to evaluate the feasibility and the conditions of use of FCM in routine clinical practice beyond the limiting criteria of clinical trials. Methods: This observational, prospective study of patients with a solid tumour or a haematological malignancy who have received treatment with FCM after 01 July 2011 evaluated data about the circumstances of iron administration, concomitant medication and laboratory tests in the period from 3 months prior to the first FCM administration (baseline) until 3 months post-baseline. Results: Data from 367 FCM-treated patients were analysed. FCM was mainly given as a single dose at baseline (69.2 %) and without additional erythropoiesis-stimulating agent (ESA, 64.3 %). The median total iron dose was 1000 mg per patient. Median haemoglobin (Hb) levels of FCM-treated patients improved from 10.3 g/dL (interquartile range 9.5, 11.1 g/dL) at baseline to 11.8 g/dL (11.1, 13.0 g/dL) until the end of the 3-month observational period. Patients treated with FCM alone or additional ESA achieved similar median Hb increase (1.3 [0.4, 2.1] g/dL and 1.4 [0.4, 2.5] g/dL, respectively). Patients with baseline Hb up to 11.0 g/dL and serum ferritin up to 500 ng/mL and beyond achieved stable median Hb levels ≥11.0 g/dL without signs of iron overload. No severe or serious adverse reaction and no hypersensitivity reactions were reported. Conclusions: The results of this observational study confirm the effectiveness and tolerability of FCM when given in clinical routine practice alone or in combination with an ESA.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalSupportive Care in Cancer
Volume24
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Anaemia
  • Chemotherapy-induced anaemia
  • Erythropoiesis-stimulating agent
  • Ferric carboxymaltose
  • Haemoglobin
  • Intravenous
  • Iron
  • Iron deficiency

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