Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy

Alexandre Dizeux; Thomas Payen; Guillaume Barrois; Capucine Baldini; Delphine Le Guillou Buffelo; Eva Comperat; Jean Luc Gennisson; Mickael Tanter; S. Lori Bridal

doi:10.1109/ULTSYM.2014.0281

Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy

Alexandre Dizeux, Thomas Payen, Guillaume Barrois, Capucine Baldini, Delphine Le Guillou Buffelo, Eva Comperat, Jean Luc Gennisson, Mickael Tanter, S. Lori Bridal

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (DCE-US) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both DCE-US and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.

Original language	English
Title of host publication	IEEE International Ultrasonics Symposium, IUS
Publisher	IEEE Computer Society
Pages	1144-1147
Number of pages	4
ISBN (Electronic)	9781479970490
DOIs	https://doi.org/10.1109/ULTSYM.2014.0281
Publication status	Published - 20 Oct 2014
Externally published	Yes
Event	2014 IEEE International Ultrasonics Symposium, IUS 2014 - Chicago, United States Duration: 3 Sept 2014 → 6 Sept 2014

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2014 IEEE International Ultrasonics Symposium, IUS 2014
Country/Territory	United States
City	Chicago
Period	3/09/14 → 6/09/14

Keywords

angiogenesis
dynamic contrast-enhanced ultrasound
fibrosis
functional vascular network
necrosis
shear wave elastography
stiffness
tumor microenvironment

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10.1109/ULTSYM.2014.0281

Cite this

Dizeux, A., Payen, T., Barrois, G., Baldini, C., Le Guillou Buffelo, D., Comperat, E., Gennisson, J. L., Tanter, M., & Bridal, S. L. (2014). Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy. In IEEE International Ultrasonics Symposium, IUS (pp. 1144-1147). Article 6931972 (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2014.0281

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title = "Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy",

abstract = "Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (DCE-US) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both DCE-US and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.",

keywords = "angiogenesis, dynamic contrast-enhanced ultrasound, fibrosis, functional vascular network, necrosis, shear wave elastography, stiffness, tumor microenvironment",

author = "Alexandre Dizeux and Thomas Payen and Guillaume Barrois and Capucine Baldini and {Le Guillou Buffelo}, Delphine and Eva Comperat and Gennisson, {Jean Luc} and Mickael Tanter and Bridal, {S. Lori}",

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year = "2014",

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day = "20",

doi = "10.1109/ULTSYM.2014.0281",

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Dizeux, A, Payen, T, Barrois, G, Baldini, C, Le Guillou Buffelo, D, Comperat, E, Gennisson, JL, Tanter, M & Bridal, SL 2014, Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy. in IEEE International Ultrasonics Symposium, IUS., 6931972, IEEE International Ultrasonics Symposium, IUS, IEEE Computer Society, pp. 1144-1147, 2014 IEEE International Ultrasonics Symposium, IUS 2014, Chicago, United States, 3/09/14. https://doi.org/10.1109/ULTSYM.2014.0281

Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy. / Dizeux, Alexandre; Payen, Thomas; Barrois, Guillaume et al.
IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society, 2014. p. 1144-1147 6931972 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy

AU - Dizeux, Alexandre

AU - Payen, Thomas

AU - Barrois, Guillaume

AU - Baldini, Capucine

AU - Le Guillou Buffelo, Delphine

AU - Comperat, Eva

AU - Gennisson, Jean Luc

AU - Tanter, Mickael

AU - Bridal, S. Lori

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AB - Robust, novel information on tumor microenvironment would improve therapeutic follow-up in oncology. Shear wave elastography (SWE) evaluates Young's modulus (stiffness) based on shear wave velocity. Dynamic contrast-enhanced ultrasound (DCE-US) traces microvascular flow with intravascular microbubbles. In this study, an ectopic tumor model was modified using two different types of drugs a cytotoxic (cyclophosphamide) and an anti-angiogenic (sunitinib). Both DCE-US and SWE imaging were sensitive to functional, physiological and mechanical modifications of the tumor and provided complementarity information to describe these modifications.

KW - angiogenesis

KW - dynamic contrast-enhanced ultrasound

KW - fibrosis

KW - functional vascular network

KW - necrosis

KW - shear wave elastography

KW - stiffness

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M3 - Conference contribution

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Dizeux A, Payen T, Barrois G, Baldini C, Le Guillou Buffelo D, Comperat E et al. Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy. In IEEE International Ultrasonics Symposium, IUS. IEEE Computer Society. 2014. p. 1144-1147. 6931972. (IEEE International Ultrasonics Symposium, IUS). doi: 10.1109/ULTSYM.2014.0281

Complementarity of shear wave elastography and dynamic contrast-enhanced ultrasound to discriminate tumor modifications during antiangiogenic and cytotoxic therapy

Abstract

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Keywords

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