Conventional type 1 dendritic cells (cDC1) in cancer immunity

Peng Liu; Liwei Zhao; Guido Kroemer; Oliver Kepp

doi:10.1186/s13062-023-00430-5

Conventional type 1 dendritic cells (cDC1) in cancer immunity

Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have gained prominence due to their unique ability to cross-present antigens and activate cytotoxic T lymphocytes. This review summarizes the distinctive characteristics of cDC1, their pivotal role in anticancer immunity, and the potential applications of cDC1-based strategies in immunotherapy.

Original language	English
Article number	71
Journal	Biology Direct
Volume	18
Issue number	1
DOIs	https://doi.org/10.1186/s13062-023-00430-5
Publication status	Published - 1 Dec 2023

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abstract = "Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have gained prominence due to their unique ability to cross-present antigens and activate cytotoxic T lymphocytes. This review summarizes the distinctive characteristics of cDC1, their pivotal role in anticancer immunity, and the potential applications of cDC1-based strategies in immunotherapy.",

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AB - Cancer immunotherapy, alone or in combination with conventional therapies, has revolutionized the landscape of antineoplastic treatments, with dendritic cells (DC) emerging as key orchestrators of anti-tumor immune responses. Among the distinct DC subsets, conventional type 1 dendritic cells (cDC1) have gained prominence due to their unique ability to cross-present antigens and activate cytotoxic T lymphocytes. This review summarizes the distinctive characteristics of cDC1, their pivotal role in anticancer immunity, and the potential applications of cDC1-based strategies in immunotherapy.

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Conventional type 1 dendritic cells (cDC1) in cancer immunity

Abstract

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