Current state of knowledge regarding the use of antiangiogenic agents with radiation therapy

Renaud Mazeron, Bethany Anderson, Stéphane Supiot, François Paris, Eric Deutsch

    Research output: Contribution to journalReview articlepeer-review

    32 Citations (Scopus)

    Abstract

    Angiogenesis has been a central theme of oncologic research for several years. Recently, improved understanding of its mechanisms has led to the development of several antiangiogenic agents. Some have demonstrated their effectiveness in large randomized studies; however, no antiangiogenic agent has yet been approved for treatment in combination with radiotherapy. Numerous preclinical studies and a few small clinical trials have recently reported encouraging results. The objective of this article is to review the concept of targeted antiangiogenic agents and the early clinical results of their use in combination with radiation therapy.

    Original languageEnglish
    Pages (from-to)476-486
    Number of pages11
    JournalCancer Treatment Reviews
    Volume37
    Issue number6
    DOIs
    Publication statusPublished - 1 Jan 2011

    Keywords

    • Antiangiogenics
    • Hypoxia
    • Normalization window of oxygenation
    • Radiotherapy

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