Cytokines in oncolytic virotherapy

Jonathan G. Pol, Samuel T. Workenhe, Prathyusha Konda, Shashi Gujar, Guido Kroemer

    Research output: Contribution to journalReview articlepeer-review

    42 Citations (Scopus)

    Abstract

    Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly exposed and released by malignant entities and their stromal accomplices. As a consequence, executioners of antitumor immunity inefficiently navigate across cancer tissues and fail to eliminate malignant targets. By inducing immunogenic cancer cell death, oncolytic viruses profoundly reshape the tumor microenvironment. They trigger the local spread of danger signals and tumor-associated (as well as viral) antigens, thus attracting antigen-presenting cells, promoting the activation and expansion of lymphocytic populations, facilitating their infiltration in the tumor bed, and reinvigorating cytotoxic immune activity. The present review recapitulates key chemokines, growth factors and other cytokines that orchestrate this ballet of antitumoral leukocytes upon oncolytic virotherapy.

    Original languageEnglish
    Pages (from-to)4-27
    Number of pages24
    JournalCytokine and Growth Factor Reviews
    Volume56
    DOIs
    Publication statusPublished - 1 Dec 2020

    Keywords

    • Chemokines
    • Growth factors
    • Interferons
    • Interleukins
    • Oncolytic virus

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