Defective Autophagy Initiates Malignant Transformation

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Guido Kroemer

    Research output: Contribution to journalShort surveypeer-review

    24 Citations (Scopus)

    Abstract

    In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria. In this issue of Molecular Cell, Park et al. (2016) elegantly demonstrate that a partial defect in autophagy supports malignant transformation as it favors the production of genotoxic reactive oxygen species by mitochondria.

    Original languageEnglish
    Pages (from-to)473-474
    Number of pages2
    JournalMolecular Cell
    Volume62
    Issue number4
    DOIs
    Publication statusPublished - 19 May 2016

    Keywords

    • Alternative splicing
    • Autophagic flux
    • Mutational rate
    • Myelodysplastic syndrome
    • Regulated cell death
    • U2AF1

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