Dendritic cells and innate defense against tumor cells

Evelyn Ullrich, Cédric Ménard, Caroline Flament, Magali Terme, Grégoire Mignot, Mathieu Bonmort, Jöel Plumas, Laurence Chaperot, Nathalie Chaput, Laurence Zitvogel

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Tumor growth results from a delicate balance between intrinsic dysregulation of oncogenes, tumor suppressor and stability genes counteracted by extrinsic defenses composed of immune cells shaping tumor immunogenicity. Although immune subversion might be the ultimate outcome of this process, a complex network of cellular interactions take place eventually leading to tumor specific cognate immune responses. The links between innate and cognate antitumor immunity eliciting protective T cell responses are instigated by cytokines, chemokines and damage associated molecular patterns. The intricate differentiation pathway whereby dendritic cells could undergo an efficient maturation program in the tumor microenvironment appears crucial. We will discuss the role of innate effectors and cancer therapies in the process of defense against tumor cells.

    Original languageEnglish
    Pages (from-to)79-92
    Number of pages14
    JournalCytokine and Growth Factor Reviews
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2008

    Keywords

    • Cancer immunity
    • Dendritic cells
    • IKDC cells
    • Innate effectors
    • NK cells

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