Der(16)t(l;16)(qll;qll) in myelodysplastic syndromes: a new non‐random abnormality characterized by cytogenic and fluorescence in situ hybridization studies

FRANCINE MUGNERET, NICOLE DASTUGUE, BERNARDINE FAVRE, ISABELLE SIDANER, BRUNO SALLES, FRANCINE HUGUET‐RIGAL, ERIC SOLARY

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18 Citations (Scopus)

Abstract

The der(16)t(l;16)(qll;qll) is a frequent recurrent rearrangement in solid tumours such as breast carcinomas and Ewings sarcomas. Recently, this abnormality was described also in multiple myeloma. We identified a der(16)t(l;16)(qll;qll) in three patients with myelodysplastic syndrome, either during preleukaemic phase (n = 2) or at the time of blastic transformation (n= 1). Breakpoints were ascertained by fluorescence in situ hybridization (FISH) using specific centromeric a‐satellite probes and whole chromosome painting for chromosome 1 and chromosome 16. These observations, combined with isolated cases of the literature, suggest that der(16)t(l;16)(qll; qll) is a non‐random abnormality associated with myelodysplastic syndromes.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalBritish Journal of Haematology
Volume90
Issue number1
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • FISH
  • myelodysplastic syndrome
  • t(l;16)
  • trisomy 8

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