Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer

Ziling Mao; Elom K. Aglago; Zhiwei Zhao; Casper Schalkwijk; Li Jiao; Heinz Freisling; Elisabete Weiderpass; David J. Hughes; Anne Kirstine Eriksen; Anne Tjønneland; Gianluca Severi; Joseph Rothwell; Marie Christine Boutron-Ruault; Verena Katzke; Rudolf Kaaks; Matthias B. Schulze; Anna Birukov; Vittorio Krogh; Salvatore Panico; Rosario Tumino; Fulvio Ricceri; H. Bas Bueno-De-mesquita; Roel C.H. Vermeulen; Inger T. Gram; Guri Skeie; Torkjel M. Sandanger; J. Ramón Quirós; Marta Crous-Bou; Maria Jose Sánchez; Pilar Amiano; María Dolores Chirlaque; Aurelio Barricarte Gurrea; Jonas Manjer; Ingegerd Johansson; Aurora Perez-Cornago; Mazda Jenab; Veronika Fedirko

doi:10.3390/nu13124435

Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer

Ziling Mao, Elom K. Aglago, Zhiwei Zhao, Casper Schalkwijk, Li Jiao, Heinz Freisling, Elisabete Weiderpass, David J. Hughes, Anne Kirstine Eriksen, Anne Tjønneland, Gianluca Severi, Joseph Rothwell, Marie Christine Boutron-Ruault, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Anna Birukov, Vittorio Krogh, Salvatore Panico, Rosario TuminoFulvio Ricceri, H. Bas Bueno-De-mesquita, Roel C.H. Vermeulen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, J. Ramón Quirós, Marta Crous-Bou, Maria Jose Sánchez, Pilar Amiano, María Dolores Chirlaque, Aurelio Barricarte Gurrea, Jonas Manjer, Ingegerd Johansson, Aurora Perez-Cornago, Mazda Jenab, Veronika Fedirko

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Abstract

Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.

Original language	English
Article number	4435
Journal	Nutrients
Volume	13
Issue number	12
DOIs	https://doi.org/10.3390/nu13124435
Publication status	Published - 1 Dec 2021
Externally published	Yes

Keywords

Advanced glycation end-products
All-cause mortality
Colorectal cancer mortality
Dietary advanced glycation end-products

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10.3390/nu13124435

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Mao, Z., Aglago, E. K., Zhao, Z., Schalkwijk, C., Jiao, L., Freisling, H., Weiderpass, E., Hughes, D. J., Eriksen, A. K., Tjønneland, A., Severi, G., Rothwell, J., Boutron-Ruault, M. C., Katzke, V., Kaaks, R., Schulze, M. B., Birukov, A., Krogh, V., Panico, S., ... Fedirko, V. (2021). Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer. Nutrients, 13(12), Article 4435. https://doi.org/10.3390/nu13124435

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title = "Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer",

abstract = "Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.",

keywords = "Advanced glycation end-products, All-cause mortality, Colorectal cancer mortality, Dietary advanced glycation end-products",

author = "Ziling Mao and Aglago, {Elom K.} and Zhiwei Zhao and Casper Schalkwijk and Li Jiao and Heinz Freisling and Elisabete Weiderpass and Hughes, {David J.} and Eriksen, {Anne Kirstine} and Anne Tj{\o}nneland and Gianluca Severi and Joseph Rothwell and Boutron-Ruault, {Marie Christine} and Verena Katzke and Rudolf Kaaks and Schulze, {Matthias B.} and Anna Birukov and Vittorio Krogh and Salvatore Panico and Rosario Tumino and Fulvio Ricceri and Bueno-De-mesquita, {H. Bas} and Vermeulen, {Roel C.H.} and Gram, {Inger T.} and Guri Skeie and Sandanger, {Torkjel M.} and Quir{\'o}s, {J. Ram{\'o}n} and Marta Crous-Bou and S{\'a}nchez, {Maria Jose} and Pilar Amiano and Chirlaque, {Mar{\'i}a Dolores} and Gurrea, {Aurelio Barricarte} and Jonas Manjer and Ingegerd Johansson and Aurora Perez-Cornago and Mazda Jenab and Veronika Fedirko",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = dec,

day = "1",

doi = "10.3390/nu13124435",

language = "English",

volume = "13",

journal = "Nutrients",

issn = "2072-6643",

number = "12",

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Mao, Z, Aglago, EK, Zhao, Z, Schalkwijk, C, Jiao, L, Freisling, H, Weiderpass, E, Hughes, DJ, Eriksen, AK, Tjønneland, A, Severi, G, Rothwell, J, Boutron-Ruault, MC, Katzke, V, Kaaks, R, Schulze, MB, Birukov, A, Krogh, V, Panico, S, Tumino, R, Ricceri, F, Bueno-De-mesquita, HB, Vermeulen, RCH, Gram, IT, Skeie, G, Sandanger, TM, Quirós, JR, Crous-Bou, M, Sánchez, MJ, Amiano, P, Chirlaque, MD, Gurrea, AB, Manjer, J, Johansson, I, Perez-Cornago, A, Jenab, M & Fedirko, V 2021, 'Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer', Nutrients, vol. 13, no. 12, 4435. https://doi.org/10.3390/nu13124435

TY - JOUR

T1 - Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer

AU - Mao, Ziling

AU - Aglago, Elom K.

AU - Zhao, Zhiwei

AU - Schalkwijk, Casper

AU - Jiao, Li

AU - Freisling, Heinz

AU - Weiderpass, Elisabete

AU - Hughes, David J.

AU - Eriksen, Anne Kirstine

AU - Tjønneland, Anne

AU - Severi, Gianluca

AU - Rothwell, Joseph

AU - Boutron-Ruault, Marie Christine

AU - Katzke, Verena

AU - Kaaks, Rudolf

AU - Schulze, Matthias B.

AU - Birukov, Anna

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Bueno-De-mesquita, H. Bas

AU - Vermeulen, Roel C.H.

AU - Gram, Inger T.

AU - Skeie, Guri

AU - Sandanger, Torkjel M.

AU - Quirós, J. Ramón

AU - Crous-Bou, Marta

AU - Sánchez, Maria Jose

AU - Amiano, Pilar

AU - Chirlaque, María Dolores

AU - Gurrea, Aurelio Barricarte

AU - Manjer, Jonas

AU - Johansson, Ingegerd

AU - Perez-Cornago, Aurora

AU - Jenab, Mazda

AU - Fedirko, Veronika

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.

AB - Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, Pinteraction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, Pinteraction = 0.003; all-cause, Pinteraction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.

KW - Advanced glycation end-products

KW - All-cause mortality

KW - Colorectal cancer mortality

KW - Dietary advanced glycation end-products

UR - http://www.scopus.com/inward/record.url?scp=85120756097&partnerID=8YFLogxK

U2 - 10.3390/nu13124435

DO - 10.3390/nu13124435

M3 - Article

C2 - 34959986

AN - SCOPUS:85120756097

SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 12

M1 - 4435

ER -

Dietary intake of advanced glycation end products (Ages) and mortality among individuals with colorectal cancer

Abstract

Keywords

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