Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical?

J. B. Micol; C. Chahine; P. L. Woerther; D. Ghez; F. Netzer; C. Dufour; M. Merad; F. Blot; E. Chachaty; S. de Botton; B. Gachot

doi:10.1111/1469-0691.12445

Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical?

J. B. Micol, C. Chahine, P. L. Woerther, D. Ghez, F. Netzer, C. Dufour, M. Merad, F. Blot, E. Chachaty, S. de Botton, B. Gachot

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Based on recommendations of the ECIL-4, we prospectively evaluated discontinuation of empirical antibiotic therapy in high-risk neutropenic acute myeloid leukaemia patients with fever of unknown origin. Seven patients (median neutropenia duration 30 days) were included. Four of them remained afebrile but quickly recovered from neutropenia. The other three had rapid recurrent fever. Two of these three patients had bacteraemia with susceptible strains and one of them was transferred to the ICU for septic shock. Median duration of sparing of antibiotics for the seven patients was 3 days (2-4). Because of these limited results the study was stopped. Clinical Microbiology and Infection

Original language	English
Pages (from-to)	O453-O455
Journal	Clinical Microbiology and Infection
Volume	20
Issue number	7
DOIs	https://doi.org/10.1111/1469-0691.12445
Publication status	Published - 1 Jan 2014

Keywords

Acute myeloid leukaemia
Antibiotic discontinuation
Bacterial resistance
Fever of unknown origin
Neutropenia

Access to Document

10.1111/1469-0691.12445

Cite this

Micol, J. B., Chahine, C., Woerther, P. L., Ghez, D., Netzer, F., Dufour, C., Merad, M., Blot, F., Chachaty, E., de Botton, S., & Gachot, B. (2014). Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical? Clinical Microbiology and Infection, 20(7), O453-O455. https://doi.org/10.1111/1469-0691.12445

@article{32bf7f2442d245f68c586e60bff04671,

title = "Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical?",

abstract = "Based on recommendations of the ECIL-4, we prospectively evaluated discontinuation of empirical antibiotic therapy in high-risk neutropenic acute myeloid leukaemia patients with fever of unknown origin. Seven patients (median neutropenia duration 30 days) were included. Four of them remained afebrile but quickly recovered from neutropenia. The other three had rapid recurrent fever. Two of these three patients had bacteraemia with susceptible strains and one of them was transferred to the ICU for septic shock. Median duration of sparing of antibiotics for the seven patients was 3 days (2-4). Because of these limited results the study was stopped. Clinical Microbiology and Infection",

keywords = "Acute myeloid leukaemia, Antibiotic discontinuation, Bacterial resistance, Fever of unknown origin, Neutropenia",

author = "Micol, {J. B.} and C. Chahine and Woerther, {P. L.} and D. Ghez and F. Netzer and C. Dufour and M. Merad and F. Blot and E. Chachaty and {de Botton}, S. and B. Gachot",

year = "2014",

month = jan,

day = "1",

doi = "10.1111/1469-0691.12445",

language = "English",

volume = "20",

pages = "O453--O455",

journal = "Clinical Microbiology and Infection",

issn = "1198-743X",

number = "7",

}

Micol, JB, Chahine, C, Woerther, PL, Ghez, D, Netzer, F, Dufour, C, Merad, M, Blot, F, Chachaty, E, de Botton, S & Gachot, B 2014, 'Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical?', Clinical Microbiology and Infection, vol. 20, no. 7, pp. O453-O455. https://doi.org/10.1111/1469-0691.12445

TY - JOUR

T1 - Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin

T2 - Is it ethical?

AU - Micol, J. B.

AU - Chahine, C.

AU - Woerther, P. L.

AU - Ghez, D.

AU - Netzer, F.

AU - Dufour, C.

AU - Merad, M.

AU - Blot, F.

AU - Chachaty, E.

AU - de Botton, S.

AU - Gachot, B.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Based on recommendations of the ECIL-4, we prospectively evaluated discontinuation of empirical antibiotic therapy in high-risk neutropenic acute myeloid leukaemia patients with fever of unknown origin. Seven patients (median neutropenia duration 30 days) were included. Four of them remained afebrile but quickly recovered from neutropenia. The other three had rapid recurrent fever. Two of these three patients had bacteraemia with susceptible strains and one of them was transferred to the ICU for septic shock. Median duration of sparing of antibiotics for the seven patients was 3 days (2-4). Because of these limited results the study was stopped. Clinical Microbiology and Infection

AB - Based on recommendations of the ECIL-4, we prospectively evaluated discontinuation of empirical antibiotic therapy in high-risk neutropenic acute myeloid leukaemia patients with fever of unknown origin. Seven patients (median neutropenia duration 30 days) were included. Four of them remained afebrile but quickly recovered from neutropenia. The other three had rapid recurrent fever. Two of these three patients had bacteraemia with susceptible strains and one of them was transferred to the ICU for septic shock. Median duration of sparing of antibiotics for the seven patients was 3 days (2-4). Because of these limited results the study was stopped. Clinical Microbiology and Infection

KW - Acute myeloid leukaemia

KW - Antibiotic discontinuation

KW - Bacterial resistance

KW - Fever of unknown origin

KW - Neutropenia

UR - http://www.scopus.com/inward/record.url?scp=84905030198&partnerID=8YFLogxK

U2 - 10.1111/1469-0691.12445

DO - 10.1111/1469-0691.12445

M3 - Article

C2 - 24313354

AN - SCOPUS:84905030198

SN - 1198-743X

VL - 20

SP - O453-O455

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

IS - 7

ER -

Discontinuation of empirical antibiotic therapy in neutropenic acute myeloid leukaemia patients with fever of unknown origin: Is it ethical?

Abstract

Keywords

Access to Document

Other files and links

Cite this