Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Philippe Jonveaux; Josette Hillion; Olivier Bernard; Maryvonne Le Coniat; Josette Derré; Maria Flexor; Christian Jacques Larsen; Roland Berger

Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Philippe Jonveaux, Josette Hillion, Olivier Bernard, Maryvonne Le Coniat, Josette Derré, Maria Flexor, Christian Jacques Larsen, Roland Berger

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

Original language	English
Pages (from-to)	2224-2227
Number of pages	4
Journal	Leukemia
Volume	8
Issue number	12
Publication status	Published - 1 Jan 1994

Cite this

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title = "Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient",

abstract = "A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.",

author = "Philippe Jonveaux and Josette Hillion and Olivier Bernard and {Le Coniat}, Maryvonne and Josette Derr{\'e} and Maria Flexor and Larsen, {Christian Jacques} and Roland Berger",

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T1 - Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

AU - Jonveaux, Philippe

AU - Hillion, Josette

AU - Bernard, Olivier

AU - Le Coniat, Maryvonne

AU - Derré, Josette

AU - Flexor, Maria

AU - Larsen, Christian Jacques

AU - Berger, Roland

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

AB - A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

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AN - SCOPUS:0028605288

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JO - Leukemia

JF - Leukemia

IS - 12

ER -

Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Abstract

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