TY - JOUR
T1 - Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population
AU - for the SAPRIS-SERO study group
AU - Lapidus, Nathanael
AU - Paireau, Juliette
AU - Levy-Bruhl, Daniel
AU - de Lamballerie, Xavier
AU - Severi, Gianluca
AU - Touvier, Mathilde
AU - Zins, Marie
AU - Cauchemez, Simon
AU - Carrat, Fabrice
N1 - Publisher Copyright:
© 2020 Elsevier Masson SAS
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Objectives: This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France. Patients and methods: A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data. Results: IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), and also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%). Conclusions: These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.
AB - Objectives: This study aimed at estimating the SARS-CoV-2 infection hospitalization (IHR) and infection fatality ratios (IFR) in France. Patients and methods: A serosurvey was conducted in 9782 subjects from the two French regions with the highest incidence of COVID-19 during the first wave of the pandemic and coupled with surveillance data. Results: IHR and IFR were 2.7% and 0.49% overall. Both were higher in men and increased exponentially with age. The relative risks of hospitalization and death were 2.1 (95% CI: 1.9-2.3) and 3.8 (2.4-4.2) per 10-year increase, meaning that IHR and IFR approximately doubled every 10 and 5 years, respectively. They were dramatically high in the very elderly (80-90 years: IHR: 26%, IFR: 9.2%), and also substantial in younger adults (40-50 years: IHR: 0.98%, IFR: 0.042%). Conclusions: These findings support the need for comprehensive preventive measures to help reduce the spread of the virus, even in young or middle-aged adults.
KW - Adult
KW - Age-Specific Death Rate
KW - COVID-19
KW - France
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85103247172&partnerID=8YFLogxK
U2 - 10.1016/j.idnow.2020.12.007
DO - 10.1016/j.idnow.2020.12.007
M3 - Article
AN - SCOPUS:85103247172
SN - 2666-9927
VL - 51
SP - 380
EP - 382
JO - Infectious Diseases Now
JF - Infectious Diseases Now
IS - 4
ER -