eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu; Allan Sauvat; Juliette Humeau; Marion Leduc; Oliver Kepp; Guido Kroemer

doi:10.1080/2162402X.2018.1431089

eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu, Allan Sauvat, Juliette Humeau, Marion Leduc, Oliver Kepp, Guido Kroemer

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56 Citations (Scopus)

Abstract

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

Original language	English
Article number	e1431089
Journal	OncoImmunology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1080/2162402X.2018.1431089
Publication status	Published - 3 Jun 2018

Keywords

ER stress
anthracyclines
cancer
chemotherapy
unfolded protein response

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10.1080/2162402X.2018.1431089

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title = "eIF2α phosphorylation: A hallmark of immunogenic cell death",

abstract = "Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.",

keywords = "ER stress, anthracyclines, cancer, chemotherapy, unfolded protein response",

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T2 - A hallmark of immunogenic cell death

AU - Bezu, Lucillia

AU - Sauvat, Allan

AU - Humeau, Juliette

AU - Leduc, Marion

AU - Kepp, Oliver

AU - Kroemer, Guido

PY - 2018/6/3

Y1 - 2018/6/3

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AB - Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

KW - ER stress

KW - anthracyclines

KW - cancer

KW - chemotherapy

KW - unfolded protein response

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ER -

eIF2α phosphorylation: A hallmark of immunogenic cell death

Abstract

Keywords

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