Emerging use of senolytics and senomorphics against aging and chronic diseases

Jan Martel; David M. Ojcius; Cheng Yeu Wu; Hsin Hsin Peng; Laurent Voisin; Jean Luc Perfettini; Yun Fei Ko; John D. Young

doi:10.1002/med.21702

Emerging use of senolytics and senomorphics against aging and chronic diseases

Jan Martel, David M. Ojcius, Cheng Yeu Wu, Hsin Hsin Peng, Laurent Voisin, Jean Luc Perfettini, Yun Fei Ko, John D. Young

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

Original language	English
Pages (from-to)	2114-2131
Number of pages	18
Journal	Medicinal Research Reviews
Volume	40
Issue number	6
DOIs	https://doi.org/10.1002/med.21702
Publication status	Published - 1 Nov 2020

Keywords

aging
apoptosis
dietary supplements
phytochemicals
senescence

Access to Document

10.1002/med.21702

Cite this

@article{57b02882719a49d38cc52bb349ee5dc7,

title = "Emerging use of senolytics and senomorphics against aging and chronic diseases",

abstract = "Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.",

keywords = "aging, apoptosis, dietary supplements, phytochemicals, senescence",

author = "Jan Martel and Ojcius, {David M.} and Wu, {Cheng Yeu} and Peng, {Hsin Hsin} and Laurent Voisin and Perfettini, {Jean Luc} and Ko, {Yun Fei} and Young, {John D.}",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC",

year = "2020",

month = nov,

day = "1",

doi = "10.1002/med.21702",

language = "English",

volume = "40",

pages = "2114--2131",

journal = "Medicinal Research Reviews",

issn = "0198-6325",

number = "6",

}

TY - JOUR

T1 - Emerging use of senolytics and senomorphics against aging and chronic diseases

AU - Martel, Jan

AU - Ojcius, David M.

AU - Wu, Cheng Yeu

AU - Peng, Hsin Hsin

AU - Voisin, Laurent

AU - Perfettini, Jean Luc

AU - Ko, Yun Fei

AU - Young, John D.

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

AB - Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

KW - aging

KW - apoptosis

KW - dietary supplements

KW - phytochemicals

KW - senescence

UR - http://www.scopus.com/inward/record.url?scp=85087179350&partnerID=8YFLogxK

U2 - 10.1002/med.21702

DO - 10.1002/med.21702

M3 - Review article

C2 - 32578904

AN - SCOPUS:85087179350

SN - 0198-6325

VL - 40

SP - 2114

EP - 2131

JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

IS - 6

ER -

Emerging use of senolytics and senomorphics against aging and chronic diseases

Abstract

Keywords

Access to Document

Other files and links

Cite this