Enteral feeding and early outcomes of patients undergoing allogeneic stem cell transplantation following myeloablative conditioning

David Seguy, Céline Berthon, Jean Baptiste Micol, Stéphane Darré, Jean Hugues Dalle, Sylvain Neuville, Francis Bauters, Jean Pierre Jouet, Ibrahim Yakoub-Agha

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87 Citations (Scopus)

Abstract

The purpose of this study was to evaluate the impact of enteral nutrition on early outcome of patients after myeloablative allogeneic stem cell transplantation (allo-SCT). From January 2001 to January 2003, 22 patients agreed to receive enteral nutrition via a nasogastric feeding tube; the remaining 23 patients received parenteral nutrition (n=22) or standard oral feeding (n=1). Early complications and factors influencing 100-day overall survival (OS) were investigated. Patients who received enteral nutrition developed less often acute-grade III/IV graft-versus-host disease (18%) than those who did not (35%) (P=0.011). In addition, this group showed lower mortality from infection during the first 100 days after transplantation. In multivariate analyses, only the absence of enteral nutrition was found to adversely influence 100-day OS with a hazard ratio of 8.3. Enteral nutrition is a safe and effective method for feeding allo-SCT patients. A randomized trial is warranted to confirm its advantage on early patient outcome.

Original languageEnglish
Pages (from-to)835-839
Number of pages5
JournalTransplantation
Volume82
Issue number6
DOIs
Publication statusPublished - 1 Sept 2006
Externally publishedYes

Keywords

  • Allogeneic stem cell transplantation
  • Early complications
  • Enteral nutrition
  • Infection

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