Abstract
ERCC1 plays a critical role in the repair of lesions in DNA induced by cisplatin. It has been demonstrated that, in patients with resected NSCLC, those with ERCC1-negative tumours had greater benefit from adjuvant chemotherapy than patients with ERCC1-positive tumours. On the other hand, patients with ERCC1-positive tumours have a better prognosis. ERCC1 can be evaluated either by the level of protein expression on immunohistochemical analysis or by quantification of its mRNA expression. At present ERCC1 appears to be a promising biomarker for predicting the benefit of cisplatin based chemotherapy and its modulation could allow sensitisation of tumour cells to this drug. Its use in daily clinical practice requires a further stage of prospective validation studies which are already in progress in patients both with completely resected NSCL or metastatic disease.
Translated title of the contribution | ERCC1 and lung cancer |
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Original language | French |
Pages (from-to) | 387-394 |
Number of pages | 8 |
Journal | Revue des Maladies Respiratoires |
Volume | 27 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 2010 |