Exosome-based immunotherapy

Nathalie Chaput; Julien Taïeb; Noël E.C. Schartz; Fabrice André; Eric Angevin; Laurence Zitvogel

doi:10.1007/s00262-003-0472-x

Exosome-based immunotherapy

Nathalie Chaput, Julien Taïeb, Noël E.C. Schartz, Fabrice André, Eric Angevin, Laurence Zitvogel

Research output: Contribution to journal › Review article › peer-review

121 Citations (Scopus)

Abstract

Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70-90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.

Original language	English
Pages (from-to)	234-239
Number of pages	6
Journal	Cancer Immunology, Immunotherapy
Volume	53
Issue number	3
DOIs	https://doi.org/10.1007/s00262-003-0472-x
Publication status	Published - 1 Mar 2004

Keywords

Cross-presentation
Exosomes
Immunotherapy
MHC complexes
Tumor

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10.1007/s00262-003-0472-x

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AU - Chaput, Nathalie

AU - Taïeb, Julien

AU - Schartz, Noël E.C.

AU - André, Fabrice

AU - Angevin, Eric

AU - Zitvogel, Laurence

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AB - Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are enriched in MHC class I and II complexes, costimulatory molecules, and hsp70-90 chaperones, and have therefore been more extensively studied for their immunomodulatory capacities in vitro and in vivo. This review will present the main biological features pertaining to tumor or DC-derived exosomes, will emphasize their immunostimulatory function, and will discuss their implementation in cancer immunotherapy.

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KW - Immunotherapy

KW - MHC complexes

KW - Tumor

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Exosome-based immunotherapy

Abstract

Keywords

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