Failure of immunosurveillance accelerates aging

Maria Perez-Lanzon; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2019.1575117

Failure of immunosurveillance accelerates aging

Maria Perez-Lanzon, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journal › Editorial

7 Citations (Scopus)

Abstract

Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.

Original language	English
Article number	e1575117
Journal	OncoImmunology
Volume	8
Issue number	4
DOIs	https://doi.org/10.1080/2162402X.2019.1575117
Publication status	Published - 3 Apr 2019

Keywords

Age-related disease
NK cells
cytotoxic T cells
immunosenescence
senescence

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10.1080/2162402X.2019.1575117

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abstract = "Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.",

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AU - Zitvogel, Laurence

AU - Kroemer, Guido

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AB - Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected.

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KW - NK cells

KW - cytotoxic T cells

KW - immunosenescence

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Failure of immunosurveillance accelerates aging

Abstract

Keywords

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