Fat-fated microglial dysfunction

Aymeric Silvin; Florent Ginhoux

doi:10.15252/embj.2018101176

Fat-fated microglial dysfunction

Aymeric Silvin, Florent Ginhoux

Research output: Contribution to journal › Comment/debate

Abstract

Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gabandé-Rodríguez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann-Pick disease type A.

Original language	English
Article number	e101176
Journal	EMBO Journal
Volume	38
Issue number	2
DOIs	https://doi.org/10.15252/embj.2018101176
Publication status	Published - 15 Jan 2019
Externally published	Yes

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@article{e60f4f62caa84ac2b07da31c4c92d175,

title = "Fat-fated microglial dysfunction",

abstract = "Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gaband{\'e}-Rodr{\'i}guez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann-Pick disease type A.",

author = "Aymeric Silvin and Florent Ginhoux",

note = "Publisher Copyright: {\textcopyright} 2018 Agency for Science, Technology and Research (A*STAR)",

year = "2019",

month = jan,

day = "15",

doi = "10.15252/embj.2018101176",

language = "English",

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T1 - Fat-fated microglial dysfunction

AU - Silvin, Aymeric

AU - Ginhoux, Florent

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gabandé-Rodríguez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann-Pick disease type A.

AB - Patients with lysosomal storage disorders (LSDs) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gabandé-Rodríguez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann-Pick disease type A.

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U2 - 10.15252/embj.2018101176

DO - 10.15252/embj.2018101176

M3 - Comment/debate

C2 - 30567721

AN - SCOPUS:85058960784

SN - 0261-4189

VL - 38

JO - EMBO Journal

JF - EMBO Journal

IS - 2

M1 - e101176

ER -

Fat-fated microglial dysfunction

Abstract

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