Fibroblast growth factor receptors across urothelial carcinoma landscape

Iris E. Ertl, Shahrokh F. Shariat, Hadi Mostafaei, Dafina Ilijazi, Yohann Loriot

    Research output: Contribution to journalReview articlepeer-review

    6 Citations (Scopus)

    Abstract

    Purpose of reviewFibroblast growth factor receptor (FGFR) signalling, especially induced by FGFR3, is a crucial factor in the pathogenesis of urothelial carcinoma and was therefore extensively studied over the last decades. In this review, we summarize the most relevant findings of the past two years.Recent findingsRecent studies support the concept that FGFR3 mediates a pathway of urothelial carcinogenesis associated with low malignant potential. FGFR3 may represent a highly accurate biomarker for diagnosis and prediction of recurrence, progression or therapy response. The pan FGFR-inhibitor erdafitinib was recently approved for urothelial carcinoma, whereas several other FGFR-targeted drugs are currently undergoing clinical trials.SummaryNumerous recent studies focus on the role of FGFR3 in different urothelial carcinoma subtypes and its potential clinical application as noninvasive biomarker, as well as therapeutic target.

    Original languageEnglish
    Pages (from-to)557-565
    Number of pages9
    JournalCurrent Opinion in Urology
    Volume30
    Issue number4
    DOIs
    Publication statusPublished - 1 Jul 2020

    Keywords

    • fibroblast growth factor receptor 3
    • fibroblast growth factor receptor inhibitors
    • fibroblast growth factor receptors
    • urothelial carcinoma

    Cite this