TY - JOUR
T1 - High Concentrations of Intrathecal Interleukin-6 in Human Bacterial and Nonbacterial Meningitis
AU - Chavanet, P.
AU - Bonnotte, B.
AU - Guiguet, M.
AU - Zeller, V.
AU - Solary, E.
AU - Maurice, L.
AU - Casasnovas, O.
AU - Caillot, D.
AU - Waldner, A.
AU - Kisterman, J. P.
AU - Portier, H.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Interleukin-6 (IL-6) is multipotent cytokine that acts in a network of factors directing the inflammatory reaction of purulent bacterial meningitis (PBM). However, little is known about the role of IL-6 in aseptic or “viral” meningitis (AM). IL-6 was assayed by RIA in cerebrospinal fluid (CSF) and serum samples obtained from patients with AM (n = 65), PBM (n = 8), and lymphocytic bacterial meningitis (LBM, n = 11). Of patients with AM, 89% had detectable IL-6 in CSF, with high IL-6 titers (median, 2160 pg/mL; 95% confidence interval [CI], 1320-2540 pg/mL) compared with 100% in patients with PBM (median, 6575 pg/mL; 95% CI, 450-32, 000 pg/mL) and 90.9% in patients with LBM (median, 875 pg/mL; 95% Cl, 150-2180 pg/mL). There was a highly symmetrical correlation between IL-6 and the percentage of polymorphonuclear cells in CSF of patients with PBM (r =.97, P =.01) and AM (r =.49, P =.002). In conclusion, this study shows evidence that IL-6 is released into the meningeal space in aseptic meningitis and is correlated with the local acute inflammatory response.
AB - Interleukin-6 (IL-6) is multipotent cytokine that acts in a network of factors directing the inflammatory reaction of purulent bacterial meningitis (PBM). However, little is known about the role of IL-6 in aseptic or “viral” meningitis (AM). IL-6 was assayed by RIA in cerebrospinal fluid (CSF) and serum samples obtained from patients with AM (n = 65), PBM (n = 8), and lymphocytic bacterial meningitis (LBM, n = 11). Of patients with AM, 89% had detectable IL-6 in CSF, with high IL-6 titers (median, 2160 pg/mL; 95% confidence interval [CI], 1320-2540 pg/mL) compared with 100% in patients with PBM (median, 6575 pg/mL; 95% CI, 450-32, 000 pg/mL) and 90.9% in patients with LBM (median, 875 pg/mL; 95% Cl, 150-2180 pg/mL). There was a highly symmetrical correlation between IL-6 and the percentage of polymorphonuclear cells in CSF of patients with PBM (r =.97, P =.01) and AM (r =.49, P =.002). In conclusion, this study shows evidence that IL-6 is released into the meningeal space in aseptic meningitis and is correlated with the local acute inflammatory response.
UR - http://www.scopus.com/inward/record.url?scp=0026772105&partnerID=8YFLogxK
U2 - 10.1093/infdis/166.2.428
DO - 10.1093/infdis/166.2.428
M3 - Article
C2 - 1634815
AN - SCOPUS:0026772105
SN - 0022-1899
VL - 166
SP - 428
EP - 431
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -